FE model for validating cell stretching experiment. (a) Quarter symmetry cell and substrate model generated in COMSOL of AR4 cell undergoing prescribed uniaxial-axial, uniaxial-transverse, and equibiaxial stretch. (b) and (c) Comparison of model and experimental cell induced substrate displacements during (b) uniaxial-axial, (c) uniaxial-transverse, and (d) equibiaxial stretch.