This paper describes a framework to quantify the effect of freestream turbulence, generated by mixing processes in a combustor, on turbulent boundary layer loss generation in the high-pressure turbine downstream of the combustor. The regime of freestream turbulence common to gas turbine aero engines is identified and it is shown that the dissipation loss coefficient in this regime can be determined using existing measurements of the effect of freestream turbulence on skin friction. The paper shows that combustor-generated freestream turbulence can increase the profile loss coefficient of a typical high-pressure turbine blade by as much as . A relation has been derived between a non-dimensional turbulence parameter, which characterizes the freestream turbulence, and the increase in turbine boundary layer dissipation, which quantifies the decrease in turbine efficiency. The relation provides guidelines for combustor turbulence modifications that lead to turbine performance benefits. The framework has been applied in example trade studies which show that increasing the size of dilution ports and increasing the length of the combustor can decrease high-pressure turbine profile loss generation to potentially increase stage efficiency up to .