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W. David Merryman
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Journal Articles

Biophysical Analysis of Dystrophic and Osteogenic Models of Valvular Calcification

Joseph Chen, Jon R. Peacock, Janelle Branch, W. David Merryman
Journal: Journal of Biomechanical Engineering
Article Type: Technical Forum
J Biomech Eng. February 2015, 137(2): 020903.
Paper No: BIO-14-1418
https://doi.org/10.1115/1.4029115
Published Online: February 1, 2015
View Article titled, Biophysical Analysis of Dystrophic and Osteogenic Models of Valvular Calcification
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Topics: Assaying, Atomic force microscopy, Biomechanics, Valves, X-rays, Bone, Biomaterials, Cellular mechanics, Statistical analysis, Biological tissues
Proceedings Papers

Strain-Dependent TGF Beta-1 Synthesis and Activation by Aortic Valve Interstitial Cells

W. David Merryman, Michael P. Nilo, Joanne E. Murphy-Ullrich
Proc. ASME. SBC2008, ASME 2008 Summer Bioengineering Conference, Parts A and B, 137-138, June 25–29, 2008
Paper No: SBC2008-192874
https://doi.org/10.1115/SBC2008-192874
View Paper titled, Strain-Dependent TGF Beta-1 Synthesis and Activation by Aortic Valve Interstitial Cells
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Topics: Valves, Aorta, Fibroblasts, Stress
Proceedings Papers

Extracellular Matrix-Contractile Response Coupling of the Aortic Heart Valve Interstitial Cell

David E. Schmidt, W. David Merryman, Michael S. Sacks
Proc. ASME. SBC2008, ASME 2008 Summer Bioengineering Conference, Parts A and B, 141-142, June 25–29, 2008
Paper No: SBC2008-193171
https://doi.org/10.1115/SBC2008-193171
View Paper titled, Extracellular Matrix-Contractile Response Coupling of the Aortic Heart Valve Interstitial Cell
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Topics: Valves, Stiffness, Biological tissues, Mechanical properties, Bending (Stress), Computational methods, Engineering simulation, Finite element model, Probes, Simulation
Proceedings Papers

The Intrinsic Durability of Aortic Valve ECM in Absence of Cellular Maintenance

Jun Liao, Erinn M. Joyce, Hugh L. Jones, Mina Tahai, Ali Borazjani, W. David Merryman, Michael S. Sacks
Proc. ASME. SBC2008, ASME 2008 Summer Bioengineering Conference, Parts A and B, 659-660, June 25–29, 2008
Paper No: SBC2008-193110
https://doi.org/10.1115/SBC2008-193110
View Paper titled, The Intrinsic Durability of Aortic Valve ECM in Absence of Cellular Maintenance
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Topics: Durability, Maintenance, Valves, Biological tissues, Design, Surgery
Proceedings Papers

Aortic Valve Interstitial Cell Viscoelasticity

W. David Merryman, Paul D. Bieniek, Farshid Guilak, Michael S. Sacks
Proc. ASME. SBC2007, ASME 2007 Summer Bioengineering Conference, 237-238, June 20–24, 2007
Paper No: SBC2007-176694
https://doi.org/10.1115/SBC2007-176694
View Paper titled, Aortic Valve Interstitial Cell Viscoelasticity
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Topics: Valves, Viscoelasticity, Biological tissues, Deformation, Durability, Mechanical properties
Proceedings Papers

Cellular Deformations in Microintegrated Electrospun Poly (Ester Urethane) Urea Scaffolds Under Biaxial Stretch

Jun Liao, W. David Merryman, Yi Hong, John Stella, Simon Watkins, William R. Wagner, Michael S. Sacks
Proc. ASME. SBC2007, ASME 2007 Summer Bioengineering Conference, 1047-1048, June 20–24, 2007
Paper No: SBC2007-176726
https://doi.org/10.1115/SBC2007-176726
View Paper titled, Cellular Deformations in Microintegrated Electrospun Poly (Ester Urethane) Urea Scaffolds Under Biaxial Stretch
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Topics: Deformation, Ester, Urethane elastomers, Biological tissues, Biodegradation, Cardiovascular system, Fibers, Maintenance, Mechanical properties, Muscle
Proceedings Papers

Collagen-Hyaluronic Acid Hydrogels Provide Enhanced EMT of Endocardial Cells

M. K. Sewell-Loftin, Daniel M. DeLaughter, Joey V. Barnett, W. David Merryman
Proc. ASME. SBC2013, Volume 1A: Abdominal Aortic Aneurysms; Active and Reactive Soft Matter; Atherosclerosis; BioFluid Mechanics; Education; Biotransport Phenomena; Bone, Joint and Spine Mechanics; Brain Injury; Cardiac Mechanics; Cardiovascular Devices, Fluids and Imaging; Cartilage and Disc Mechanics; Cell and Tissue Engineering; Cerebral Aneurysms; Computational Biofluid Dynamics; Device Design, Human Dynamics, and Rehabilitation; Drug Delivery and Disease Treatment; Engineered Cellular Environments, V01AT15A002, June 26–29, 2013
Paper No: SBC2013-14204
https://doi.org/10.1115/SBC2013-14204
View Paper titled, Collagen-Hyaluronic Acid Hydrogels Provide Enhanced EMT of Endocardial Cells
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Topics: Artificial limbs, Biological tissues, Biomechanics, Heart valve prostheses, Hydrogels, Prostheses, Risk, Thrombosis, Valves
Proceedings Papers

Cadherin-11 Regulates Calcific Nodule Formation by Aortic Valve Interstitial Cells

Joseph Chen, Joshua D. Hutcheson, M. K. Sewell-Loftin, Larisa M. Ryzhova, Charles I. Fisher, W. David Merryman
Proc. ASME. SBC2013, Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions, V01BT50A001, June 26–29, 2013
Paper No: SBC2013-14201
https://doi.org/10.1115/SBC2013-14201
View Paper titled, Cadherin-11 Regulates Calcific Nodule Formation by Aortic Valve Interstitial Cells
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Topics: Valves, Diseases, Myocardium, Stress
Proceedings Papers

Four Week Durability of Combined RF Ablation and Cryo-Anchoring Treatment for Mitral Valve Prolapse

Steven M. Boronyak, W. David Merryman
Proc. ASME. SBC2013, Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions, V01BT30A002, June 26–29, 2013
Paper No: SBC2013-14198
https://doi.org/10.1115/SBC2013-14198
View Paper titled, Four Week Durability of Combined RF Ablation and Cryo-Anchoring Treatment for Mitral Valve Prolapse
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Topics: Durability, Radiofrequency ablation, Valves, Biological tissues, Stiffness, Ablation (Vaporization technology), Bioreactors, Catheters, Maintenance, Mechanical testing
Proceedings Papers

Biaxial Compliance Changes of Mitral Valve Leaflets Following Radiofrequency Ablation

Carolyn G. Norwood, W. David Merryman
Proc. ASME. SBC2009, ASME 2009 Summer Bioengineering Conference, Parts A and B, 79-80, June 17–21, 2009
Paper No: SBC2009-206761
https://doi.org/10.1115/SBC2009-206761
View Paper titled, Biaxial Compliance Changes of Mitral Valve Leaflets Following Radiofrequency Ablation
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Topics: Radiofrequency ablation, Valves, Annulus, Blood flow
Proceedings Papers

Micromechanical Analysis of Mouse Aortic Valve Leaflets With Atomic Force Microscopy

M. K. Sewell-Loftin, Christopher B. Brown, H. Scott Baldwin, W. David Merryman
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 1273-1274, June 20–23, 2012
Paper No: SBC2012-80500
https://doi.org/10.1115/SBC2012-80500
View Paper titled, Micromechanical Analysis of Mouse Aortic Valve Leaflets With Atomic Force Microscopy
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Topics: Atomic force microscopy, Valves, Biological tissues, Biomechanics, Surgery, Diseases
Proceedings Papers

5-HT2B Antagonism Inhibits Strain- and Cytokine-Dependent Formation of Calcific Nodules by Aortic Valve Interstitial Cells

Joshua D. Hutcheson, Joseph Chen, Larisa M. Ryzhova, W. David Merryman
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 1039-1040, June 20–23, 2012
Paper No: SBC2012-80496
https://doi.org/10.1115/SBC2012-80496
View Paper titled, 5-HT2B Antagonism Inhibits Strain- and Cytokine-Dependent Formation of Calcific Nodules by Aortic Valve Interstitial Cells
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Topics: Valves, Diseases, Biological tissues, Biomechanics, Drugs, Muscle, Nucleation (Physics), Performance
Proceedings Papers

Aortic Valve Interstitial Cell Activation Does Not Occur at Low Tissue Stiffness During Embryogenesis

Young Wook Chun, Joey Barnett, W. David Merryman
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 1041-1042, June 20–23, 2012
Paper No: SBC2012-80501
https://doi.org/10.1115/SBC2012-80501
View Paper titled, Aortic Valve Interstitial Cell Activation Does Not Occur at Low Tissue Stiffness During Embryogenesis
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Topics: Biological tissues, Stiffness, Valves, Diseases, Vickers hardness testing, Artificial limbs, Design, Enzymes, Maintenance, Osteoblasts
Proceedings Papers

Biomechanical Effects of Radiofrequency Ablation With Simultaneous Cryogenic Anchoring

Steven M. Boronyak, W. David Merryman
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 805-806, June 20–23, 2012
Paper No: SBC2012-80494
https://doi.org/10.1115/SBC2012-80494
View Paper titled, Biomechanical Effects of Radiofrequency Ablation With Simultaneous Cryogenic Anchoring
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Topics: Biomechanics, Diseases, Flow (Dynamics), Radiofrequency ablation, Surgery, Valves
Proceedings Papers

Integrin-Focal Adhesion Coupling and Substrate Stiffness Affect Smooth Muscle Alpha Actin Expression in Fibroblasts

Alison K. Schroer, W. David Merryman
Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 331-332, June 20–23, 2012
Paper No: SBC2012-80887
https://doi.org/10.1115/SBC2012-80887
View Paper titled, Integrin-Focal Adhesion Coupling and Substrate Stiffness Affect Smooth Muscle Alpha Actin Expression in Fibroblasts
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Topics: Adhesion, Fibroblasts, Muscle, Stiffness, Biological tissues, Diseases, Stress, Atherosclerosis, Fibers, Lung
Proceedings Papers

Radiofrequency Ablation With a Cryogenically Cooled Catheter to Percutaneously Treat Mitral Valve Prolapse

Steven M. Boronyak, W. David Merryman
Proc. ASME. SBC2011, ASME 2011 Summer Bioengineering Conference, Parts A and B, 179-180, June 22–25, 2011
Paper No: SBC2011-53911
https://doi.org/10.1115/SBC2011-53911
View Paper titled, Radiofrequency Ablation With a Cryogenically Cooled Catheter to Percutaneously Treat Mitral Valve Prolapse
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Topics: Catheters, Radiofrequency ablation, Valves, Diseases, Flow (Dynamics), Surgery
Proceedings Papers

The Role of SRC in Strain- and Ligand- Dependent Phenotypic Modulation of Mouse Embryonic Fibroblasts

M. K. Sewell-Loftin, W. David Merryman
Proc. ASME. SBC2011, ASME 2011 Summer Bioengineering Conference, Parts A and B, 337-338, June 22–25, 2011
Paper No: SBC2011-53604
https://doi.org/10.1115/SBC2011-53604
View Paper titled, The Role of SRC in Strain- and Ligand- Dependent Phenotypic Modulation of Mouse Embryonic Fibroblasts
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Topics: Fibroblasts, Biological tissues, Diseases, Proteins, Atherosclerosis, Construction, Muscle, Patient treatment, Stiffness, Valves
Proceedings Papers

Strain and Substrate Stiffness Affect Calcium Accumulation in Aortic Valve Interstitial Cells

Joshua D. Hutcheson, M. K. Sewell-Loftin, W. David Merryman
Proc. ASME. SBC2011, ASME 2011 Summer Bioengineering Conference, Parts A and B, 1209-1210, June 22–25, 2011
Paper No: SBC2011-53611
https://doi.org/10.1115/SBC2011-53611
View Paper titled, Strain and Substrate Stiffness Affect Calcium Accumulation in Aortic Valve Interstitial Cells
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Topics: Stiffness, Valves, Biological tissues, Biomechanics, Cultured cells, Diseases, Failure, Muscle, Nucleation (Physics)
Proceedings Papers

Calcific Nodule Morphogenesis by Aortic Valve Interstitial Cells: Synergism of Applied Strain and TGF-β1

Joseph Chen, Charles I. Fisher, M. K. Sewell-Loftin, W. David Merryman
Proc. ASME. SBC2011, ASME 2011 Summer Bioengineering Conference, Parts A and B, 243-244, June 22–25, 2011
Paper No: SBC2011-53899
https://doi.org/10.1115/SBC2011-53899
View Paper titled, Calcific Nodule Morphogenesis by Aortic Valve Interstitial Cells: Synergism of Applied Strain and TGF-β1
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Topics: Valves, Diseases, Stiffness, Cardiovascular system, Osteoblasts
Proceedings Papers

Serotonin Antagonists Prevent Cytokine and Mechanical Activation of Aortic Valve Interstitial Cells

Joshua D. Hutcheson, W. David Merryman
Proc. ASME. SBC2010, ASME 2010 Summer Bioengineering Conference, Parts A and B, 279-280, June 16–19, 2010
Paper No: SBC2010-19389
https://doi.org/10.1115/SBC2010-19389
View Paper titled, Serotonin Antagonists Prevent Cytokine and Mechanical Activation of Aortic Valve Interstitial Cells
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Topics: Valves, Cardiovascular system, Diseases, Risk, Surgery