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Journal Articles

Effect of Articular Surface Compression on Cartilage Extracellular Matrix Deformation

Peter A. Torzilli, Samie N. Allen

J Biomech Eng. September 2022, 144(9): 091007.

Paper No: BIO-21-1390

DOI: https://doi.org/10.1115/1.4054108

Published Online: March 30, 2022

View Article titled, Effect of Articular Surface Compression on Cartilage Extracellular Matrix Deformation

Topics: Cartilage, Creep, Stress, Deformation, Fluids

Proceedings Papers

Thermal Modification of Collagen

Peter A. Torzilli, Michael S. Wall, Xiang-Hua Deng, Stephen J. O’Brien, Russell F. Warren

Proc. ASME. IMECE99, Advances in Bioengineering, 97-98, November 14–19, 1999

Paper No: IMECE1999-0395

DOI: https://doi.org/10.1115/IMECE1999-0395

View Paper titled, Thermal Modification of Collagen

Topics: Biological tissues, Mechanical properties, Shrinkage (Materials), Temperature

Proceedings Papers

Development of an In Vivo Rabbit Model for Cartilage Trauma: Influence of Impact Stress Magnitude on Chondrocyte Death

Dejan Milentijevic, Allan Liew, Peter A. Torzilli

Proc. ASME. IMECE2001, Advances in Bioengineering, 125-126, November 11–16, 2001

Paper No: IMECE2001/BED-23062

DOI: https://doi.org/10.1115/IMECE2001/BED-23062

View Paper titled, Development of an In Vivo Rabbit Model for Cartilage Trauma: Influence of Impact Stress Magnitude on Chondrocyte Death

Topics: Cartilage, Chondrocytes, Stress, Biological tissues, Damage, Potential energy, Wounds

Proceedings Papers

Biomechanical Properties of Grown Cartilage Are Decreased in the Presence of Retinoic Acid, Chondroitinase ABC and Ibuprofen

Chih-Tung Chen, Peter A. Torzilli, Kenneth W. Fishbein, Richard G. S. Spencer, Walter E. Horton

Proc. ASME. IMECE2001, Advances in Bioengineering, 297-298, November 11–16, 2001

Paper No: IMECE2001/BED-23148

DOI: https://doi.org/10.1115/IMECE2001/BED-23148

View Paper titled, Biomechanical Properties of Grown Cartilage Are Decreased in the Presence of Retinoic Acid, Chondroitinase ABC and Ibuprofen

Topics: Biomechanics, Cartilage, Biological tissues, Bioreactors, Design, Fibers, Magnetic resonance, Maintenance

Proceedings Papers

Deformation-Dependent Enzyme Cleavage of Collagen

Karla E.-K. Wyatt, Jonathan W. Bourne, Peter A. Torzilli

Proc. ASME. SBC2007, ASME 2007 Summer Bioengineering Conference, 785-786, June 20–24, 2007

Paper No: SBC2007-176502

DOI: https://doi.org/10.1115/SBC2007-176502

View Paper titled, Deformation-Dependent Enzyme Cleavage of Collagen

Topics: Deformation, Enzymes, Chain, Diseases, Maintenance, Musculoskeletal system, Separation (Technology)

Proceedings Papers

Leukocytes Cause Inflammatory Response to Traumatized Articular Cartilage in Acute Phase of Joint Injury

Dejan Milentijevic, David M. Green, Koosha Aslani, Peter A. Torzilli, Russell F. Warren

Proc. ASME. SBC2007, ASME 2007 Summer Bioengineering Conference, 603-604, June 20–24, 2007

Paper No: SBC2007-176402

DOI: https://doi.org/10.1115/SBC2007-176402

View Paper titled, Leukocytes Cause Inflammatory Response to Traumatized Articular Cartilage in Acute Phase of Joint Injury

Topics: Cartilage, Leukocytes, Wounds, Chondrocytes, Blood, Osteoarthritis, Oxygen, Transients (Dynamics)

Proceedings Papers

Load Down-Regulates TNF-Alpha Induced Cartilage Degradation in Part Through NF-KB and P38 Pathways

Valerie M. Wolfe, Seonghun Park, Marjana Tomic, Peter A. Torzilli, C. T. Christopher Chen

Proc. ASME. SBC2007, ASME 2007 Summer Bioengineering Conference, 819-820, June 20–24, 2007

Paper No: SBC2007-176541

DOI: https://doi.org/10.1115/SBC2007-176541

View Paper titled, Load Down-Regulates TNF-Alpha Induced Cartilage Degradation in Part Through NF-KB and P38 Pathways

Topics: Cartilage, Stress, Compression, Cascades (Fluid dynamics), Diseases, Enzymes, Tumors, Wounds

Proceedings Papers

Collagen Molecular Conformation Exhibits Strain-Rate Dependent Response to Axial Deformation in Silico

Jonathan W. Bourne, Peter A. Torzilli

Proc. ASME. SBC2009, ASME 2009 Summer Bioengineering Conference, Parts A and B, 995-996, June 17–21, 2009

Paper No: SBC2009-205534

DOI: https://doi.org/10.1115/SBC2009-205534

View Paper titled, Collagen Molecular Conformation Exhibits Strain-Rate Dependent Response to Axial Deformation in Silico

Topics: Biological tissues, Deformation, Enzymes, Molecular conformation, Proteins

Proceedings Papers

Covalent Cross-Linking Accelerates Collagen Enzyme Mechano-Kinetic Cleavage: Nanomechanics Predicts Microscale Behavior

Jonathan W. Bourne, Jared M. Lippell, Peter A. Torzilli

Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 1157-1158, June 20–23, 2012

Paper No: SBC2012-80392

DOI: https://doi.org/10.1115/SBC2012-80392

View Paper titled, Covalent Cross-Linking Accelerates Collagen Enzyme Mechano-Kinetic Cleavage: Nanomechanics Predicts Microscale Behavior

Topics: Enzymes, Microscale devices, Biological tissues, Blood vessels, Cartilage, Compression, Structural elements (Construction), Tendons, Tensile strength, Tension

Proceedings Papers

Development of an In Vitro Cartilage Degradation Model to Emulate Early-Stage Osteoarthritis

Stephanie Grenier, Peter A. Torzilli, Madhu Bhargava

Proc. ASME. SBC2012, ASME 2012 Summer Bioengineering Conference, Parts A and B, 707-708, June 20–23, 2012

Paper No: SBC2012-80042

DOI: https://doi.org/10.1115/SBC2012-80042

View Paper titled, Development of an In Vitro Cartilage Degradation Model to Emulate Early-Stage Osteoarthritis

Topics: Cartilage, Osteoarthritis, Damage, Diseases, Biomechanics, Permeability, Porosity

Proceedings Papers

In Silico Molecular Modeling of Collagen Crosslink Loading

Jonathan W. Bourne, Peter A. Torzilli

Proc. ASME. SBC2011, ASME 2011 Summer Bioengineering Conference, Parts A and B, 403-404, June 22–25, 2011

Paper No: SBC2011-53352

DOI: https://doi.org/10.1115/SBC2011-53352

View Paper titled, In Silico Molecular Modeling of Collagen Crosslink Loading

Topics: Biological tissues, Blood vessels, Cartilage, Compression, Enzymes, Modeling, Proteins, Tendons, Tension

Journal Articles

A Novel Device to Apply Controlled Flexion and Extension to the Rat Knee Following Anterior Cruciate Ligament Reconstruction

Mark E. Stasiak, Dan Wiznia, Saif Alzoobaee, Michael C. Ciccotti, Carl W. Imhauser, Clifford Voigt, Peter A. Torzilli, Xiang-Hua Deng, Scott A. Rodeo

J Biomech Eng. April 2012, 134(4): 041008.

DOI: https://doi.org/10.1115/1.4006341

Published Online: April 27, 2012

View Article titled, A Novel Device to Apply Controlled Flexion and Extension to the Rat Knee Following Anterior Cruciate Ligament Reconstruction

Topics: Anterior cruciate ligament, Cycles, Knee, Stress, Tendons, Bone, Rotation

Journal Articles

Deformation-Dependent Enzyme Mechanokinetic Cleavage of Type I Collagen

Karla E.-K. Wyatt, Jonathan W. Bourne, Peter A. Torzilli

J Biomech Eng. May 2009, 131(5): 051004.

DOI: https://doi.org/10.1115/1.3078177

Published Online: March 24, 2009

View Article titled, Deformation-Dependent Enzyme Mechanokinetic Cleavage of Type I Collagen

Topics: Deformation, Elongation, Enzymes, Fibers, Relaxation (Physics), Stress, Tendons, Equilibrium (Physics), Water

Proceedings Papers

Chondrocyte Death in Articular Cartilage Due to Excessive Mechanical Loading in the Axial and Transverse Directions

Chih-Tung Chen, Peter A. Torzilli

Proc. ASME. IMECE2002, Advances in Bioengineering, 51-52, November 17–22, 2002

Paper No: IMECE2002-32669

DOI: https://doi.org/10.1115/IMECE2002-32669

View Paper titled, Chondrocyte Death in Articular Cartilage Due to Excessive Mechanical Loading in the Axial and Transverse Directions

Topics: Cartilage, Chondrocytes, Stress, Osteoarthritis, Risk, Wounds

Proceedings Papers

Hypo-Osmolarity Decreases the Ability of Cells in Articular Cartilage to Survive a Load-Induced Injury

Adam Levin, Peter A. Torzilli, C. T. Christopher Chen

Proc. ASME. IMECE2003, Advances in Bioengineering, 125-126, November 15–21, 2003

Paper No: IMECE2003-43022

DOI: https://doi.org/10.1115/IMECE2003-43022

View Paper titled, Hypo-Osmolarity Decreases the Ability of Cells in Articular Cartilage to Survive a Load-Induced Injury

Topics: Cartilage, Stress, Wounds, Chondrocytes, Compression, Membranes

Proceedings Papers

Strain Is the Major Factor for Chondrocyte Death in Articular Cartilage Under Static Load

Amit K. Shah, Li-Jen Yuan, Peter A. Torzilli, C. T. Christopher Chen

Proc. ASME. IMECE2003, Advances in Bioengineering, 331-334, November 15–21, 2003

Paper No: IMECE2003-43059

DOI: https://doi.org/10.1115/IMECE2003-43059

View Paper titled, Strain Is the Major Factor for Chondrocyte Death in Articular Cartilage Under Static Load

Topics: Cartilage, Chondrocytes, Stress, Computer software, Wounds

Journal Articles

Influence of Stress Magnitude on Water Loss and Chondrocyte Viability in Impacted Articular Cartilage

Dejan Milentijevic, David L. Helfet, Peter A. Torzilli

J Biomech Eng. October 2003, 125(5): 594–601.

DOI: https://doi.org/10.1115/1.1610021

Published Online: October 9, 2003

View Article titled, Influence of Stress Magnitude on Water Loss and Chondrocyte Viability in Impacted Articular Cartilage

Topics: Biological tissues, Cartilage, Chondrocytes, Stress, Water, Deformation, Compression

Journal citation

NARROW

Effect of Articular Surface Compression on Cartilage Extracellular Matrix Deformation

Thermal Modification of Collagen

Development of an In Vivo Rabbit Model for Cartilage Trauma: Influence of Impact Stress Magnitude on Chondrocyte Death

Biomechanical Properties of Grown Cartilage Are Decreased in the Presence of Retinoic Acid, Chondroitinase ABC and Ibuprofen

Deformation-Dependent Enzyme Cleavage of Collagen

Leukocytes Cause Inflammatory Response to Traumatized Articular Cartilage in Acute Phase of Joint Injury

Load Down-Regulates TNF-Alpha Induced Cartilage Degradation in Part Through NF-KB and P38 Pathways

Collagen Molecular Conformation Exhibits Strain-Rate Dependent Response to Axial Deformation in Silico

Covalent Cross-Linking Accelerates Collagen Enzyme Mechano-Kinetic Cleavage: Nanomechanics Predicts Microscale Behavior

Development of an In Vitro Cartilage Degradation Model to Emulate Early-Stage Osteoarthritis

In Silico Molecular Modeling of Collagen Crosslink Loading

A Novel Device to Apply Controlled Flexion and Extension to the Rat Knee Following Anterior Cruciate Ligament Reconstruction

Deformation-Dependent Enzyme Mechanokinetic Cleavage of Type I Collagen

Chondrocyte Death in Articular Cartilage Due to Excessive Mechanical Loading in the Axial and Transverse Directions

Hypo-Osmolarity Decreases the Ability of Cells in Articular Cartilage to Survive a Load-Induced Injury

Strain Is the Major Factor for Chondrocyte Death in Articular Cartilage Under Static Load

Influence of Stress Magnitude on Water Loss and Chondrocyte Viability in Impacted Articular Cartilage

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