Low-alloy steels are extensively used in pressure boundary components of nuclear power plants. The structural integrity of the components made of low-alloy steels can be evaluated by the flaw evaluation procedure provided by Section XI of the ASME Boiler and Pressure Vessel Code. According to the Code, the stress intensity factor range ΔK can be used to determine the fatigue crack growth rates of the material. However, it has been reported that the fatigue crack growth rate under severe reversing loads is also strongly influenced by crack closure behavior. This paper discusses the relation between applied stresses and the fatigue crack growth rate for cracks in low-alloy steels exposed to air. Compressive-tensile cyclic loadings are applied to center-notched plates to obtain the fatigue crack growth curves. The test data demonstrate that effective stress intensity factor range predicted by our closure model described the crack growth property more accurately. A comparison among crack closure models indicates that our crack closure model is suitable to predict the crack growth rates when low constraint conditions are assumed at the crack tip due to severe reversing loads.