Acute chest syndrome (ACS) is a leading cause of death for those with sickle cell disease (SCD). ACS is defined by the development of a new pulmonary infiltrate on chest X-ray, with fever and respiratory symptoms. Efforts have been made to apply various technologies in the hospital setting to provide earlier detection of ACS than X-ray, but they are expensive, increase radiation exposure to the patient, and are not technologies that are easily transferrable for home use to help with early diagnosis. We present preliminary studies on patients suggesting that acoustical measurements recorded quantitatively with contact sensors (electronic stethoscopes) and analyzed using advanced computational analysis methods may provide an earlier diagnostic indicator of the onset of ACS than is possible with current clinical practice. Novel in silico models of respiratory acoustics utilizing image-based and algorithmically developed lungs with full conducting airway trees support and help explain measured acoustic trends and provide guidance on the next steps in developing and translating a diagnostic approach. More broadly, the experimental and computational techniques introduced herein, while focused on monitoring and predicting the onset of ACS, could catalyze further advances in mobile health (mhealth)-enabled, computer-based auscultative diagnoses for a wide range of cardiopulmonary pathologies.
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Early Acoustic Warning for the Onset of Acute Chest Syndrome in Sickle Cell Patients
Brian Henry,
Brian Henry
Richard and Loan Hill
Department of Bioengineering,
University of Illinois at Chicago,
Chicago, IL 60607
Department of Bioengineering,
University of Illinois at Chicago,
Chicago, IL 60607
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Gardner Yost,
Gardner Yost
Richard and Loan Hill
Department of Bioengineering,
University of Illinois at Chicago,
Chicago, IL 60607
Department of Bioengineering,
University of Illinois at Chicago,
Chicago, IL 60607
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Robert Molokie,
Robert Molokie
Department of Medicine,
University of Illinois at Chicago,
Chicago, IL 60612;
University of Illinois at Chicago,
Chicago, IL 60612;
Jesse Brown VA Medical Center,
Chicago, IL 60612
Chicago, IL 60612
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Thomas J. Royston
Thomas J. Royston
Richard and Loan Hill
Department of Bioengineering,
University of Illinois at Chicago,
Chicago, IL 60607
Department of Bioengineering,
University of Illinois at Chicago,
Chicago, IL 60607
Search for other works by this author on:
Brian Henry
Richard and Loan Hill
Department of Bioengineering,
University of Illinois at Chicago,
Chicago, IL 60607
Department of Bioengineering,
University of Illinois at Chicago,
Chicago, IL 60607
Gardner Yost
Richard and Loan Hill
Department of Bioengineering,
University of Illinois at Chicago,
Chicago, IL 60607
Department of Bioengineering,
University of Illinois at Chicago,
Chicago, IL 60607
Robert Molokie
Department of Medicine,
University of Illinois at Chicago,
Chicago, IL 60612;
University of Illinois at Chicago,
Chicago, IL 60612;
Jesse Brown VA Medical Center,
Chicago, IL 60612
Chicago, IL 60612
Thomas J. Royston
Richard and Loan Hill
Department of Bioengineering,
University of Illinois at Chicago,
Chicago, IL 60607
Department of Bioengineering,
University of Illinois at Chicago,
Chicago, IL 60607
Manuscript received October 2, 2017; final manuscript received January 15, 2018; published online March 7, 2018. Editor: Ahmed Al-Jumaily.
ASME J of Medical Diagnostics. May 2018, 1(2): 021006 (7 pages)
Published Online: March 7, 2018
Article history
Received:
October 2, 2017
Revised:
January 15, 2018
Citation
Henry, B., Yost, G., Molokie, R., and Royston, T. J. (March 7, 2018). "Early Acoustic Warning for the Onset of Acute Chest Syndrome in Sickle Cell Patients." ASME. ASME J of Medical Diagnostics. May 2018; 1(2): 021006. https://doi.org/10.1115/1.4039177
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