Studies have suggested that elevated cerebrospinal fluid (CSF) pressure can have a damaging effect on the optic nerve and visual acuity. There is need for a noninvasive CSF pressure measurement technique. A portable device for noninvasive intracranial pressure (ICP) monitoring would have a significant impact on clinical care. A proof-of-concept prototype is used to test the feasibility of a technique for monitoring ICP changes. The proposed methodology utilizes transcranial Doppler ultrasonography to monitor blood flow through the ophthalmic and central retinal arteries while forces are applied to the cornea by a controlled actuator. Control algorithms for the device were developed and tested using an integrated experimental platform. Preliminary results using tissue-mimicking materials show the ability to differentiate between materials of differing stiffness that simulates different levels of ICP. These experiments are an initial step toward a handheld noninvasive ICP monitoring device.

References

1.
Morgan
,
W.
,
Yu
,
D.
, and
Balaratnasingam
,
C.
,
2008
, “
The Role of Cerebrospinal Fluid Pressure in Glaucoma Pathophysiology: The Dark Side of the Optic Disc
,”
J. Glaucoma
,
17
(
5
), pp.
408
413
.10.1097/IJG.0b013e31815c5f7c
2.
Yang
,
Y.
,
Yu
,
M.
,
Zhu
,
J.
,
Chen
,
X.
, and
Liu
,
X.
,
2010
, “
Role of Cerebrospinal Fluid in Glaucoma: Pressure and Beyond
,”
Med. Hypotheses
,
74
(
1
), pp.
31
34
.10.1016/j.mehy.2009.08.024
3.
Ren
,
R.
,
Jonas
,
J.
,
Tian
,
G.
,
Zhen
,
Y.
,
Ma
,
K.
,
Li
,
S.
,
Wang
,
H.
,
Li
,
B.
,
Zhang
,
X.
, and
Wang
,
N.
,
2010
, “
Cerebrospinal Fluid Pressure in Glaucoma: A Prospective Study
,”
Ophthalmology
,
117
(
2
), pp.
259
266
.10.1016/j.ophtha.2009.06.058
4.
Jonas
,
J.
, and
Wang
,
N.
,
2012
, “
Association Between Arterial Blood Pressure, Cerebrospinal Fluid Pressure and Intraocular Pressure in the Pathophysiology of Optic Nerve Head Diseases
,”
Clin. Exp. Ophthalmol.
,
40
(
4
), pp.
e233
e234
.10.1111/j.1442-9071.2011.02625.x
5.
Fogarty
,
J. A.
,
Otto
,
C.
,
Kerstman
,
E.
,
Oubre
,
C.
, and
Wu
,
J.
,
2011
, “
The Visual Impairment Intracranial Pressure Summit Report
,” NASA Johnson Space Center, Houston, TX, Report No. NASA/TP-2011-216160.
6.
Bruce
,
2014
, “
Noninvasive Assessment of Cerebrospinal Fluid Pressure
,”
J. Neuro-Ophth.
,
34
(
3
), pp.
288
294
.10.1097/WNO.0000000000000153
7.
Miller
,
M.
,
Chang
,
T.
,
Keating
,
R.
,
Crouch
,
E.
, and
Sable
,
C.
,
2009
, “
Blood Flow Velocities are Reduced in the Optic Nerve of Children With Elevated Intracranial Pressure
,”
J. Child Neurol.
,
24
(
1
), pp.
30
35
.10.1177/0883073808321050
8.
Klingerhofer
,
J.
,
Conrad
,
B.
,
Benecke
,
R.
, and
Sander
,
D.
,
1987
, “
Intracranial Flow Patterns at Increasing Intracranial Pressure
,”
J. Mol. Med.
,
65
(
12
), pp.
542
545
.10.1007/BF01727619
9.
Bhatia
,
A.
, and
Grupta
,
A.
,
2007
, “
Neuromonitoring in the Intensive Care Unit. Intracranial Pressure and Cerebral Blood Flow Monitoring
,”
Intens. Care Med.
,
33
(
7
), pp.
1263
1271
.10.1007/s00134-007-0678-z
10.
Stalmans
,
I.
,
Vandewalle
,
E.
,
Anderson
,
D.
,
Costa
,
V. P.
,
Frenkel
,
R. E. P.
,
Garhofer
,
G.
,
Grunwald
,
J.
,
Gugleta
,
K.
,
Harris
,
A.
,
Hudson
,
C.
,
Januleviciene
,
I.
,
Kagemann
,
L.
,
Kergoat
,
H.
,
Lovasik
,
J. V.
,
Lanzl
,
I.
,
Martinez
,
A.
,
Nguyen
,
Q. D.
,
Plange
,
N.
,
Reitsamer
,
H. A.
,
Sehi
,
M.
,
Siesky
,
B.
,
Zeitz
,
O.
,
Orgül
,
S.
, and
Schmetterer
,
L.
,
2011
, “
Use of Colour Doppler Imaging in Ocular Blood Flow Research
,”
Acta Ophthalmol.
,
89
(
8
), pp.
e609
e630
.10.1111/j.1755-3768.2011.02178.x
11.
Sharma
,
V.
,
Tsiugoulis
,
G.
,
Lao
,
A.
, and
Alexandrov
,
A.
,
2007
, “
Role of Transcranial Doppler Ultrasonography in Evaluation of Patients With Cerebrovascular Disease
,”
Curr. Neurol. Neurosci.
,
7
(
1
), pp.
8
20
.10.1007/s11910-007-0016-4
12.
Jensen
,
J.
,
1996
,
Estimation of Blood Velocities Using Ultrasound: A Signal Processing Approach
,
Cambridge University
,
New York
.
13.
Kay
,
M.
,
1995
, “
Color Doppler Imaging in Disorders of the Orbit, Retina, and Optic Nerve
,”
Semin. Ophthalmol.
,
10
(
3
), pp.
242
250
.10.3109/08820539509060978
14.
Ragauskas
,
A.
,
Daubaris
,
G.
,
Dziugys
,
A.
,
Azelis
,
V.
, and
Gedrimas
,
V.
,
2005
, “
Innovative Non-Invasive Measurement for Absolute Intracranial Pressure Measurement Without Calibration
,”
Intracranial Pressure and Brain Monitoring XII
(Acta Neurochirurgica Supplementum, Vol. 95), Springer, Vienna, pp.
357
361
.10.1007/3-211-32318-X_73
15.
Ragauskas
,
A.
,
Matijosaitis
,
V.
,
Zakelis
,
R.
,
Petrikonis
,
K.
,
Rastenyte
,
D.
,
Piper
,
I.
, and
Daubaris
,
G.
,
2012
, “
Clinical Assessment of Noninvasive Intracranial Pressure Absolute Value Measurement Method
,”
Neurology
,
78
(
21
), pp.
1684
1691
.10.1212/WNL.0b013e3182574f50
16.
Nusbaum
,
D.
,
2011
, “
Two-Depth Transcranial Doppler: A Novel Approach for Non-Invasive Absolute Intracranial Pressure Measurement
,”
Aviat. Space Environ. Med.
,
82
(
11
), pp.
1080
1081
.10.3357/ASEM.3137.2011
17.
Smooth-On
,
2013
, “
Ecoflex Supersoft Silicone Products
,” Smooth-On Inc., Macungie, PA, http://www.smooth-on.com/Silicone-Rubber-an/c2_1115_1130/index.html
You do not currently have access to this content.