Studies have suggested that elevated cerebrospinal fluid (CSF) pressure can have a damaging effect on the optic nerve and visual acuity. There is need for a noninvasive CSF pressure measurement technique. A portable device for noninvasive intracranial pressure (ICP) monitoring would have a significant impact on clinical care. A proof-of-concept prototype is used to test the feasibility of a technique for monitoring ICP changes. The proposed methodology utilizes transcranial Doppler ultrasonography to monitor blood flow through the ophthalmic and central retinal arteries while forces are applied to the cornea by a controlled actuator. Control algorithms for the device were developed and tested using an integrated experimental platform. Preliminary results using tissue-mimicking materials show the ability to differentiate between materials of differing stiffness that simulates different levels of ICP. These experiments are an initial step toward a handheld noninvasive ICP monitoring device.
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June 2015
Technical Briefs
Proof-of-Concept Prototype for Noninvasive Intracranial Pressure Monitoring Using Ocular Hemodynamics Under Applied Force
Tyler Ketchem,
Tyler Ketchem
Department of Mechanical & Materials Engineering,
W342 Nebraska Hall,
e-mail: tketchem@hotmail.com
University of Nebraska–Lincoln
,W342 Nebraska Hall,
Lincoln, NE 68588-0526
e-mail: tketchem@hotmail.com
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Max Twedt,
Max Twedt
Department of Biological Systems Engineering,
223 Chase Hall,
e-mail: mhtwedt@gmail.com
University of Nebraska–Lincoln
,223 Chase Hall,
Lincoln, NE 68583
e-mail: mhtwedt@gmail.com
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Darrin Lim,
Darrin Lim
Department of Biomedical Engineering,
Box 98651,
e-mail: darrin.lim@duke.edu
Duke University
,Box 98651,
Durham, NC 27708
e-mail: darrin.lim@duke.edu
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Greg Bashford,
Greg Bashford
Department of Biological Systems Engineering,
230 L.W. Chase Hall,
e-mail: gbashford2@unl.edu
University of Nebraska–Lincoln
,230 L.W. Chase Hall,
Lincoln, NE 68583
e-mail: gbashford2@unl.edu
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Jeff A. Hawks
Jeff A. Hawks
1
Mem. ASME
Mechanical & Materials Engineering Department,
W342 Nebraska Hall,
P.O. Box 880526,
e-mail: jhawks2@unl.edu
Mechanical & Materials Engineering Department,
University of Nebraska–Lincoln
,W342 Nebraska Hall,
P.O. Box 880526,
Lincoln, NE 68588-0526
e-mail: jhawks2@unl.edu
1Corresponding author.
Search for other works by this author on:
Tyler Ketchem
Department of Mechanical & Materials Engineering,
W342 Nebraska Hall,
e-mail: tketchem@hotmail.com
University of Nebraska–Lincoln
,W342 Nebraska Hall,
Lincoln, NE 68588-0526
e-mail: tketchem@hotmail.com
Max Twedt
Department of Biological Systems Engineering,
223 Chase Hall,
e-mail: mhtwedt@gmail.com
University of Nebraska–Lincoln
,223 Chase Hall,
Lincoln, NE 68583
e-mail: mhtwedt@gmail.com
Darrin Lim
Department of Biomedical Engineering,
Box 98651,
e-mail: darrin.lim@duke.edu
Duke University
,Box 98651,
Durham, NC 27708
e-mail: darrin.lim@duke.edu
Greg Bashford
Department of Biological Systems Engineering,
230 L.W. Chase Hall,
e-mail: gbashford2@unl.edu
University of Nebraska–Lincoln
,230 L.W. Chase Hall,
Lincoln, NE 68583
e-mail: gbashford2@unl.edu
Jeff A. Hawks
Mem. ASME
Mechanical & Materials Engineering Department,
W342 Nebraska Hall,
P.O. Box 880526,
e-mail: jhawks2@unl.edu
Mechanical & Materials Engineering Department,
University of Nebraska–Lincoln
,W342 Nebraska Hall,
P.O. Box 880526,
Lincoln, NE 68588-0526
e-mail: jhawks2@unl.edu
1Corresponding author.
Manuscript received March 25, 2014; final manuscript received January 31, 2015; published online April 24, 2015. Assoc. Editor: Rosaire Mongrain.
J. Med. Devices. Jun 2015, 9(2): 024502 (4 pages)
Published Online: June 1, 2015
Article history
Received:
March 25, 2014
Revision Received:
January 31, 2015
Online:
April 24, 2015
Citation
Ketchem, T., Twedt, M., Lim, D., Bashford, G., and Hawks, J. A. (June 1, 2015). "Proof-of-Concept Prototype for Noninvasive Intracranial Pressure Monitoring Using Ocular Hemodynamics Under Applied Force." ASME. J. Med. Devices. June 2015; 9(2): 024502. https://doi.org/10.1115/1.4029810
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