Tissue ablation has secured a prominent place in medicine: Such procedures involve skillful manipulations of the target tissues so as to destroy undesired structures (e.g., tumors) to restore normal structure and function. Currently, several ablative modalities are commonly employed in clinical practice, for example, radiofrequency ablation, cryoablation (Cryo), chemo-ablation, and/or high intensity focused ultrasound (HIFU). Although believed to be generally safe procedures, in small percentage of cases, these treatments can cause collateral damage of surrounding vital structures which can have severe clinical implications. Hence, a thorough understanding of tissue responses to ablation is essential to not only maximize the efficacies of ablative procedures but also minimize related clinical complications. The purpose of this study was to quantify changes in physiological/electromechanical properties of various tissues (myocardium, diaphragm, and esophagus) using in vitro tissue-bath studies, i.e., before and after treatment with one of the aforementioned ablative modalities. The functional parameters assessed were...
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Department Biomedical Engineering,
University of Minnesota,
University of Minnesota
Computer Engineering;
Department of Medical Devices Center,
University of Minnesota,
University of Minnesota,
Department Biomedical Engineering;
Department of Integrative Biology & Physiology;
Institute for Engineering in Medicine,
University of Minnesota,
Article navigation
June 2014
Technical Briefs
Physiological Tissue Response to Various Ablative Modalities1
Ashish Singal,
Department Biomedical Engineering,
University of Minnesota,
Ashish Singal
Department of Surgery
;Department Biomedical Engineering,
University of Minnesota,
Minneapolis, MN 55455
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Charles L. Soule,
University of Minnesota
Charles L. Soule
Department of Surgery
,University of Minnesota
Minneapolis, MN 55455
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John R. Ballard,
Computer Engineering;
Department of Medical Devices Center,
University of Minnesota,
John R. Ballard
Department of Electrical and
Computer Engineering;
Department of Medical Devices Center,
University of Minnesota,
Minneapolis, MN 55455
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Erik N. Cressman,
University of Minnesota,
Erik N. Cressman
Department of Interventional Radiology
,University of Minnesota,
Minneapolis, MN 55455
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Paul A. Iaizzo
Department Biomedical Engineering;
Department of Integrative Biology & Physiology;
Institute for Engineering in Medicine,
University of Minnesota,
Paul A. Iaizzo
Department of Surgery
;Department Biomedical Engineering;
Department of Integrative Biology & Physiology;
Institute for Engineering in Medicine,
University of Minnesota,
Minneapolis, MN 55455
Search for other works by this author on:
Ashish Singal
Department of Surgery
;Department Biomedical Engineering,
University of Minnesota,
Minneapolis, MN 55455
Charles L. Soule
Department of Surgery
,University of Minnesota
Minneapolis, MN 55455
John R. Ballard
Department of Electrical and
Computer Engineering;
Department of Medical Devices Center,
University of Minnesota,
Minneapolis, MN 55455
Erik N. Cressman
Department of Interventional Radiology
,University of Minnesota,
Minneapolis, MN 55455
Paul A. Iaizzo
Department of Surgery
;Department Biomedical Engineering;
Department of Integrative Biology & Physiology;
Institute for Engineering in Medicine,
University of Minnesota,
Minneapolis, MN 55455
DOI: 10.1115/1.4027006
Manuscript received February 21, 2014; final manuscript received February 28, 2014; published online April 28, 2014. Editor: Arthur G. Erdman.
J. Med. Devices. Jun 2014, 8(2): 020906 (3 pages)
Published Online: April 28, 2014
Article history
Received:
February 21, 2014
Revision Received:
February 28, 2014
Citation
Singal, A., Soule, C. L., Ballard, J. R., Cressman, E. N., and Iaizzo, P. A. (April 28, 2014). "Physiological Tissue Response to Various Ablative Modalities." ASME. J. Med. Devices. June 2014; 8(2): 020906. https://doi.org/10.1115/1.4027006
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