In medical jet injection, a narrow fluid drug stream is propelled at high velocity into skin without a needle. Previous studies have shown that the volume delivered is highly dependent on a number of factors. This paper details the development of an electronic force sensor for medical jet injection and shows that the normal contact force exerted on the tissue by the nozzle is an additional factor affecting volume delivered. Using this sensor, we measure the forces at the nozzle tip in the normal direction with a sensitivity of 18 μN, calibrated over a range from 1 N to 8 N with a mean absolute error of 8 mN, and a maximum overload of 300 N. We further measure forces at the nozzle tip in the lateral direction with a sensitivity of 8 μN, calibrated over a range from 0.1 N to 7 N, with a mean absolute error of 101 mN for lateral contact force magnitude and 1.60 deg for lateral contact force direction. Experimental validation confirms that the force sensor does not adversely affect the accuracy and precision of ejected volume from the jet injector. We use this setup to examine the effect of normal contact force on volume delivered into postmortem porcine tissue. Experimental results demonstrate that volume delivered with normal contact force between 4 N and 8 N is significantly more accurate and precise compared to volume delivered with normal contact force between 0 N and 3.9 N.
Skip Nav Destination
Article navigation
June 2019
Research-Article
An Electronic Force Sensor for Medical Jet Injection
Nickolas P. Demas,
Nickolas P. Demas
BioInstrumentation Laboratory,
Department of Mechanical Engineering,
Massachusetts Institute of Technology,
Cambridge, MA 02139
e-mail: demas@alum.mit.edu
Department of Mechanical Engineering,
Massachusetts Institute of Technology,
Cambridge, MA 02139
e-mail: demas@alum.mit.edu
1Corresponding author.
Search for other works by this author on:
Ian W. Hunter
Ian W. Hunter
George N. Hatsopoulos
Professor in Thermodynamics,
BioInstrumentation Laboratory,
Department of Mechanical Engineering,
Massachusetts Institute of Technology,
Cambridge, MA 02139
e-mail: ihunter@mit.edu
Professor in Thermodynamics,
BioInstrumentation Laboratory,
Department of Mechanical Engineering,
Massachusetts Institute of Technology,
Cambridge, MA 02139
e-mail: ihunter@mit.edu
Search for other works by this author on:
Nickolas P. Demas
BioInstrumentation Laboratory,
Department of Mechanical Engineering,
Massachusetts Institute of Technology,
Cambridge, MA 02139
e-mail: demas@alum.mit.edu
Department of Mechanical Engineering,
Massachusetts Institute of Technology,
Cambridge, MA 02139
e-mail: demas@alum.mit.edu
Ian W. Hunter
George N. Hatsopoulos
Professor in Thermodynamics,
BioInstrumentation Laboratory,
Department of Mechanical Engineering,
Massachusetts Institute of Technology,
Cambridge, MA 02139
e-mail: ihunter@mit.edu
Professor in Thermodynamics,
BioInstrumentation Laboratory,
Department of Mechanical Engineering,
Massachusetts Institute of Technology,
Cambridge, MA 02139
e-mail: ihunter@mit.edu
1Corresponding author.
Manuscript received July 11, 2018; final manuscript received February 28, 2019; published online April 11, 2019. Assoc. Editor: Michael Eggen.
J. Med. Devices. Jun 2019, 13(2): 021007 (8 pages)
Published Online: April 11, 2019
Article history
Received:
July 11, 2018
Revised:
February 28, 2019
Citation
Demas, N. P., and Hunter, I. W. (April 11, 2019). "An Electronic Force Sensor for Medical Jet Injection." ASME. J. Med. Devices. June 2019; 13(2): 021007. https://doi.org/10.1115/1.4043196
Download citation file:
Get Email Alerts
Cited By
Development of an Anatomically Accurate Three-Dimensional Simulation Model for Pediatric Central Line Placement
J. Med. Devices (March 2024)
Related Articles
High-Speed Jet Injector for Pharmaceutical Applications
J. Med. Devices (September,2022)
A New Actuation System With Simulated Electrocardiogram Signal for MR Elastography
J. Med. Devices (June,2010)
Miniaturized Cutting Tool With Triaxial Force Sensing Capabilities for Minimally Invasive Surgery
J. Med. Devices (September,2007)
An Improved Smart Ankle Foot Othosis Design Using Dual Fluid Power Cylinders
J. Med. Devices (June,2010)
Related Proceedings Papers
Related Chapters
Internal and Near Nozzle Flow Simulations of Gasoline Multi-Hole Injector (ECN Spray G) with Transient Needle Motion
Proceedings of the 10th International Symposium on Cavitation (CAV2018)
Antilock-Braking System Using Fuzzy Logic
International Conference on Mechanical and Electrical Technology, 3rd, (ICMET-China 2011), Volumes 1–3
Medicine Distribution Security and Quality Monitoring System Based to RFID
International Conference on Advanced Computer Theory and Engineering, 4th (ICACTE 2011)