Aortic valve replacement is a common procedure for many patients when their native aortic valve malfunction either because of aortic stenosis or aortic insufficiency. Due to the superior hemodynamic performance, Bio-prosthetic heart valve (bPHV) has been implanted in a large number of patients. bPHVs, however, have a number of drawbacks, including mechanically induced fatigue and leaflet tearing and calcification. Many of these complications are thought to be linked to hemodynamic factors and the mechanical forces imparted by the blood flow on blood cells. Previous works have shown that valve hemodynamics is greatly influenced by the fluid-structure interaction (FSI) of blood flow with tissues and/or valve leaflets, and the location where the valve is surgically implanted.

In this work, we report a new development of advanced numerical algorithm to simulate fluid-structure interaction between the tri-leaflet aortic valve and blood flow in physiologic conditions. Our novel computational hemodynamic framework is specifically tailored...

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