Hemolysis is a challenging problem and still represents a frequent source of errors in blood test laboratory practice. Due to the broad and heterogeneous bias induced in the measurement of several parameters by hemolysis, inaccurate results may be reported, and the patient may be required to repeat sample collection, delaying diagnosis. Existing automated laboratory devices including hemolysis detection are not suitable for lower volume and smaller sample collection sites. In many situations, hemolysis is still detected by visual inspection of the sample after centrifugation, during the blood test pre-analytical stage. Visual inspection is highly dependent on a qualified workforce, subjective to interpretation discrepancies, and thus difficult to standardize. The paper aims to describe the design and performance of a portable device for measuring hemolyzed samples based on computer vision and neural network. The results indicate that the device provides hemolysis indexes with sufficient accuracy to guide laboratory decision in the blood test pre-analytical stage.
Skip Nav Destination
Article navigation
June 2019
Research-Article
Portable Device for Measuring Blood Test Hemolyzed Samples Based on Computer Vision and Neural Network
Karyn Martinelli Lopes,
Karyn Martinelli Lopes
Department of Production Engineering,
Polytechnic School at the
University of Sao Paulo,
Professor Almeida Prado Avenue, 128,
Sao Paulo, SP 05508-070, Brazil
e-mail: kmlopes@usp.br
Polytechnic School at the
University of Sao Paulo,
Professor Almeida Prado Avenue, 128,
Sao Paulo, SP 05508-070, Brazil
e-mail: kmlopes@usp.br
Search for other works by this author on:
Flavia Helena da Silva,
Flavia Helena da Silva
Fleury Group,
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: flavia.silva@grupofleury.com.br
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: flavia.silva@grupofleury.com.br
Search for other works by this author on:
Alessandra S. Gil Maldonado,
Alessandra S. Gil Maldonado
Fleury Group,
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: alessandra.maldonado@grupofleury.com.br
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: alessandra.maldonado@grupofleury.com.br
Search for other works by this author on:
Simone Aparecida Santiago,
Simone Aparecida Santiago
Fleury Group,
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: simone.santiago@grupofleury.com.br
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: simone.santiago@grupofleury.com.br
Search for other works by this author on:
Tavani A. Pires,
Tavani A. Pires
Fleury Group,
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: tavani.pires@grupofleury.com.br
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: tavani.pires@grupofleury.com.br
Search for other works by this author on:
Claudia Maria Ferrer,
Claudia Maria Ferrer
Fleury Group,
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: claudia.ferrer@grupofleury.com.br
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: claudia.ferrer@grupofleury.com.br
Search for other works by this author on:
Sara Josa Mena,
Sara Josa Mena
Fleury Group,
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: sara.mena@grupofleury.com.br
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: sara.mena@grupofleury.com.br
Search for other works by this author on:
Maria Emilia Germani Moura,
Maria Emilia Germani Moura
Fleury Group,
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: mariaemilia.moura@grupofleury.com.br
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: mariaemilia.moura@grupofleury.com.br
Search for other works by this author on:
Pietro Teruya Domingues,
Pietro Teruya Domingues
Department of Mechatronics Engineering,
Polytechnic School at the
University of Sao Paulo,
Professor Mello Moraes Avenue, 2231,
Sao Paulo, SP 05508-030, Brazil
e-mail: pietro.domingues@usp.br
Polytechnic School at the
University of Sao Paulo,
Professor Mello Moraes Avenue, 2231,
Sao Paulo, SP 05508-030, Brazil
e-mail: pietro.domingues@usp.br
Search for other works by this author on:
Lincoln Makoto Kawakami,
Lincoln Makoto Kawakami
Department of Electronic Systems Engineering,
Polytechnic School at the
University of Sao Paulo,
Professor Luciano Gualberto Avenue, 158,
Sao Paulo, SP 05508-010, Brazil
e-mail: lincoln.kawakami@usp.br
Polytechnic School at the
University of Sao Paulo,
Professor Luciano Gualberto Avenue, 158,
Sao Paulo, SP 05508-010, Brazil
e-mail: lincoln.kawakami@usp.br
Search for other works by this author on:
Eduardo de Senzi Zancul
Eduardo de Senzi Zancul
Department of Production Engineering,
Polytechnic School at the
University of Sao Paulo,
Professor Almeida Prado Avenue, 128,
Sao Paulo, SP 05508-070, Brazil
e-mail: ezancul@usp.br
Polytechnic School at the
University of Sao Paulo,
Professor Almeida Prado Avenue, 128,
Sao Paulo, SP 05508-070, Brazil
e-mail: ezancul@usp.br
Search for other works by this author on:
Karyn Martinelli Lopes
Department of Production Engineering,
Polytechnic School at the
University of Sao Paulo,
Professor Almeida Prado Avenue, 128,
Sao Paulo, SP 05508-070, Brazil
e-mail: kmlopes@usp.br
Polytechnic School at the
University of Sao Paulo,
Professor Almeida Prado Avenue, 128,
Sao Paulo, SP 05508-070, Brazil
e-mail: kmlopes@usp.br
Flavia Helena da Silva
Fleury Group,
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: flavia.silva@grupofleury.com.br
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: flavia.silva@grupofleury.com.br
Alessandra S. Gil Maldonado
Fleury Group,
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: alessandra.maldonado@grupofleury.com.br
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: alessandra.maldonado@grupofleury.com.br
Simone Aparecida Santiago
Fleury Group,
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: simone.santiago@grupofleury.com.br
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: simone.santiago@grupofleury.com.br
Tavani A. Pires
Fleury Group,
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: tavani.pires@grupofleury.com.br
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: tavani.pires@grupofleury.com.br
Claudia Maria Ferrer
Fleury Group,
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: claudia.ferrer@grupofleury.com.br
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: claudia.ferrer@grupofleury.com.br
Sara Josa Mena
Fleury Group,
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: sara.mena@grupofleury.com.br
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: sara.mena@grupofleury.com.br
Maria Emilia Germani Moura
Fleury Group,
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: mariaemilia.moura@grupofleury.com.br
Clinical Analysis,
General Valdomiro de Lima Avenue, 508,
Sao Paulo, SP 04344-070, Brazil
e-mail: mariaemilia.moura@grupofleury.com.br
Pietro Teruya Domingues
Department of Mechatronics Engineering,
Polytechnic School at the
University of Sao Paulo,
Professor Mello Moraes Avenue, 2231,
Sao Paulo, SP 05508-030, Brazil
e-mail: pietro.domingues@usp.br
Polytechnic School at the
University of Sao Paulo,
Professor Mello Moraes Avenue, 2231,
Sao Paulo, SP 05508-030, Brazil
e-mail: pietro.domingues@usp.br
Lincoln Makoto Kawakami
Department of Electronic Systems Engineering,
Polytechnic School at the
University of Sao Paulo,
Professor Luciano Gualberto Avenue, 158,
Sao Paulo, SP 05508-010, Brazil
e-mail: lincoln.kawakami@usp.br
Polytechnic School at the
University of Sao Paulo,
Professor Luciano Gualberto Avenue, 158,
Sao Paulo, SP 05508-010, Brazil
e-mail: lincoln.kawakami@usp.br
Eduardo de Senzi Zancul
Department of Production Engineering,
Polytechnic School at the
University of Sao Paulo,
Professor Almeida Prado Avenue, 128,
Sao Paulo, SP 05508-070, Brazil
e-mail: ezancul@usp.br
Polytechnic School at the
University of Sao Paulo,
Professor Almeida Prado Avenue, 128,
Sao Paulo, SP 05508-070, Brazil
e-mail: ezancul@usp.br
Manuscript received June 4, 2018; final manuscript received February 27, 2019; published online April 4, 2019. Assoc. Editor: Chris Rylander.
J. Med. Devices. Jun 2019, 13(2): 021004 (8 pages)
Published Online: April 4, 2019
Article history
Received:
June 4, 2018
Revised:
February 27, 2019
Citation
Lopes, K. M., da Silva, F. H., Gil Maldonado, A. S., Santiago, S. A., Pires, T. A., Ferrer, C. M., Mena, S. J., Moura, M. E. G., Domingues, P. T., Kawakami, L. M., and de Senzi Zancul, E. (April 4, 2019). "Portable Device for Measuring Blood Test Hemolyzed Samples Based on Computer Vision and Neural Network." ASME. J. Med. Devices. June 2019; 13(2): 021004. https://doi.org/10.1115/1.4043078
Download citation file:
234
Views
0
Citations
Get Email Alerts
Cited By
Elliptical Trainer Redesign to Diversify Muscles Recruitment
J. Med. Devices (September 2022)
High-Speed Jet Injector for Pharmaceutical Applications
J. Med. Devices (September 2022)
DynaRing: A Patient-Specific Mitral Annuloplasty Ring With Selective Stiffness Segments
J. Med. Devices (September 2022)
Scale Effects on Performance of BLDC Micromotors for Internal Biomedical Applications: A Finite Element Analysis
J. Med. Devices (September 2022)
Related Articles
Pixel-Classification-Based Reticulocyte Detection in Blood-Smear Microscopy Images
J. Med. Devices (December,2019)
Automatic Vibrotactile Device for Interruption of Apnea in Premature Infants
J. Med. Devices (June,2010)
Adjusting to Mother Nature
Mechanical Engineering (July,1999)
Dynamical Relations for Left Ventricular Ejection: Flow Rate, Momentum, Force and Impulse
J Biomech Eng (February,1984)
Related Proceedings Papers
Related Chapters
Image Smoothing Based on Game of Life
International Conference on Advanced Computer Theory and Engineering (ICACTE 2009)
Introduction
Mechanical Blood Trauma in Circulatory-Assist Devices
Concluding remarks
Mechanical Blood Trauma in Circulatory-Assist Devices