The results of experiments investigating heat transfer from a hot wire in a binary mixture of air and helium are reported. The measurements were made with a constant temperature anemometer at low Reynolds numbers (0.25<Re<1.2) and correlated by treating the data in terms of a suitably defined Reynolds and Nusselt numbers based on the wire diameter. The correlation was obtained by taking into account the temperature dependency of gas properties, properties of binary gas mixtures, and the fluid slip at the probe surfaces as well as gas accommodation effects. The correlation has been used to measure velocity and velocity-density statistics across a buoyancy driven Rayleigh–Taylor mixing layer with a hot wire. The measured values obtained with the correlation agree well with measurements obtained with a more rigorous and extensive calibration technique (at two different overheat ratios). The reported correlation technique can be used as a faster and less expensive method for calibrating hot wires in binary gas mixtures.

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