This study introduces a framework for co-simulating neuromuscular dynamics and knee joint mechanics during gait. A knee model was developed that included 17 ligament bundles and a representation of the distributed contact between a femoral component and tibial insert surface. The knee was incorporated into a forward dynamics musculoskeletal model of the lower extremity. A computed muscle control algorithm was then used to modulate the muscle excitations to drive the model to closely track measured hip, knee, and ankle angle trajectories of a subject walking overground with an instrumented knee replacement. The resulting simulations predicted the muscle forces, ligament forces, secondary knee kinematics, and tibiofemoral contact loads. Model-predicted tibiofemoral contact forces were of comparable magnitudes to experimental measurements, with peak medial (1.95 body weight (BW)) and total (2.76 BW) contact forces within 4–17% of measured values. Average root-mean-square errors over a gait cycle were 0.26, 0.42, and 0.51 BW for the medial, lateral, and total contact forces, respectively. The model was subsequently used to predict variations in joint contact pressure that could arise by altering the frontal plane joint alignment. Small variations (±2 deg) in the alignment of the femoral component and tibial insert did not substantially affect the location of contact pressure, but did alter the medio-lateral distribution of load and internal tibia rotation in swing. Thus, the computational framework can be used to virtually assess the coupled influence of both physiological and design factors on in vivo joint mechanics and performance.
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February 2014
Research-Article
Co-Simulation of Neuromuscular Dynamics and Knee Mechanics During Human Walking
Darryl G. Thelen,
Darryl G. Thelen
1
Department of Mechanical Engineering
,University of Wisconsin-Madison
,Madison, WI 53706
;Department of Biomedical Engineering,
University of Wisconsin-Madison
,Madison, WI 53706
;Department of Orthopedics and Rehabilitation,
e-mail: thelen@engr.wisc.edu
University of Wisconsin-Madison
,Madison, WI 53706
e-mail: thelen@engr.wisc.edu
1Corresponding author.
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Kwang Won Choi,
Kwang Won Choi
Department of Mechanical Engineering,
University of Wisconsin-Madison
,Madison, WI 53706
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Anne M. Schmitz
Anne M. Schmitz
Department of Biomedical Engineering,
University of Wisconsin-Madison
,Madison, WI 53706
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Darryl G. Thelen
Department of Mechanical Engineering
,University of Wisconsin-Madison
,Madison, WI 53706
;Department of Biomedical Engineering,
University of Wisconsin-Madison
,Madison, WI 53706
;Department of Orthopedics and Rehabilitation,
e-mail: thelen@engr.wisc.edu
University of Wisconsin-Madison
,Madison, WI 53706
e-mail: thelen@engr.wisc.edu
Kwang Won Choi
Department of Mechanical Engineering,
University of Wisconsin-Madison
,Madison, WI 53706
Anne M. Schmitz
Department of Biomedical Engineering,
University of Wisconsin-Madison
,Madison, WI 53706
1Corresponding author.
Contributed by the Bioengineering Division of ASME for publication in the Journal of Biomechanical Engineering. Manuscript received September 6, 2013; final manuscript received December 19, 2013; accepted manuscript posted December 26, 2013; published online February 5, 2014. Editor: Beth Winkelstein.
J Biomech Eng. Feb 2014, 136(2): 021033 (8 pages)
Published Online: February 5, 2014
Article history
Received:
September 6, 2013
Revision Received:
December 19, 2013
Accepted:
December 26, 2013
Citation
Thelen, D. G., Won Choi, K., and Schmitz, A. M. (February 5, 2014). "Co-Simulation of Neuromuscular Dynamics and Knee Mechanics During Human Walking." ASME. J Biomech Eng. February 2014; 136(2): 021033. https://doi.org/10.1115/1.4026358
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