Fractures resulting in impaired healing can be treated with mechanical stimulation via external fixators. To examine the effect of mechanical stimulation on fracture healing, we developed an external fixator for use in a mouse model. A 0.5 mm tibial osteotomy was stabilized with the external fixator in C57BL/6 mice. Osteotomies in the treatment group (nt = 41) were subjected to daily sessions of 150 μm of controlled displacement with the aim to create a more mineralized callus at 21 days compared with the control group (nc = 39). Qualitative assessment of the histology found no notable difference in healing patterns between groups at 7, 12, 17, and 21 days. At 21 days, micro-computed tomography (CT) analysis showed that the control group had a significantly higher bone volume (BV) fraction and trabecular number compared with treatment; however there was no significant difference in the total volume (TV) of the callus or trabecular thickness between groups. In summary, the external fixator was used with a motion application system to apply controlled displacement to a healing fracture; however, this treatment did not result in a more mineralized callus at 21 days.
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Research-Article
Controlled Cyclic Compression of an Open Tibial Fracture Using an External Fixator Affects Fracture Healing in Mice
Jennifer A. Currey,
Jennifer A. Currey
1
Bioengineering Program,
e-mail: curreyj@union.edu
Union College
,807 Union Street
,Schenectady, NY 12308
e-mail: curreyj@union.edu
1Corresponding author.
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Megan Mancuso,
Megan Mancuso
Bioengineering Program,
Union College
,807 Union Street
,Schenectady, NY 12308
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Sylvie Kalikoff,
Sylvie Kalikoff
Bioengineering Program,
Union College
,807 Union Street
,Schenectady, NY 12308
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Erin Miller,
Erin Miller
Biomedical Engineering Department,
Rensselaer Polytechnic Institute
,110 8th Street
,Troy, NY 12180
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Sean Day
Sean Day
Bioengineering Program,
Union College
,807 Union Street
,Schenectady, NY 12308
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Jennifer A. Currey
Bioengineering Program,
e-mail: curreyj@union.edu
Union College
,807 Union Street
,Schenectady, NY 12308
e-mail: curreyj@union.edu
Megan Mancuso
Bioengineering Program,
Union College
,807 Union Street
,Schenectady, NY 12308
Sylvie Kalikoff
Bioengineering Program,
Union College
,807 Union Street
,Schenectady, NY 12308
Erin Miller
Biomedical Engineering Department,
Rensselaer Polytechnic Institute
,110 8th Street
,Troy, NY 12180
Sean Day
Bioengineering Program,
Union College
,807 Union Street
,Schenectady, NY 12308
1Corresponding author.
Manuscript received August 13, 2014; final manuscript received January 22, 2015; published online March 25, 2015. Assoc. Editor: Pasquale Vena.
J Biomech Eng. May 2015, 137(5): 051011 (6 pages)
Published Online: May 1, 2015
Article history
Received:
August 13, 2014
Revision Received:
January 22, 2015
Online:
March 25, 2015
Citation
Currey, J. A., Mancuso, M., Kalikoff, S., Miller, E., and Day, S. (May 1, 2015). "Controlled Cyclic Compression of an Open Tibial Fracture Using an External Fixator Affects Fracture Healing in Mice." ASME. J Biomech Eng. May 2015; 137(5): 051011. https://doi.org/10.1115/1.4029983
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