Sex differences in the mechanical properties of different musculoskeletal tissues and their impact on tendon function and disease are becoming increasingly recognized. Tendon mechanical properties are influenced by the presence or absence of sex hormones and these effects appear to be tendon- or ligament-specific. The objective of this study was to determine how sex and hormone differences in rats affect supraspinatus tendon and muscle properties. We hypothesized that male supraspinatus tendons would have increased cross-sectional area but no differences in tendon material properties or muscle composition when compared to supraspinatus tendons from female or ovariectomized (OVX) female rats. Uninjured supraspinatus tendons and muscles from male, female, and OVX female rats were collected and mechanical and histological properties were determined. Our analysis demonstrated decreased dynamic modulus and increased hysteresis and cross-sectional area in male tendons. We found that male tendons exhibited decreased dynamic modulus (during low strain frequency sweep and high strain fatigue loading), increased hysteresis, and increased cross-sectional area compared to female and OVX female tendons. Despite robust mechanical differences, tendon cell density and shape, and muscle composition remained unchanged between groups. Interestingly, these differences were unique compared to previously reported sex differences in rat Achilles tendons, which further supports the concept that the effect of sex on tendon varies anatomically. These differences may partially provide a mechanistic explanation for the increased rate of acute supraspinatus tendon ruptures seen in young males.
Skip Nav Destination
Article navigation
January 2019
Research-Article
Supraspinatus Tendons Have Different Mechanical Properties Across Sex
K. A. Bonilla,
K. A. Bonilla
McKay Orthopaedic Laboratory,
University of Pennsylvania,
Philadelphia, PA 19104
University of Pennsylvania,
Philadelphia, PA 19104
Search for other works by this author on:
A. M. Pardes,
A. M. Pardes
McKay Orthopaedic Laboratory,
University of Pennsylvania,
Philadelphia, PA 19104
University of Pennsylvania,
Philadelphia, PA 19104
Search for other works by this author on:
B. R. Freedman,
B. R. Freedman
McKay Orthopaedic Laboratory,
University of Pennsylvania,
Philadelphia, PA 19104;
University of Pennsylvania,
Philadelphia, PA 19104;
John A. Paulson School of Engineering
and Applied Sciences,
Harvard University,
Cambridge, MA 02138;
and Applied Sciences,
Harvard University,
Cambridge, MA 02138;
Wyss Institute for Biologically
Inspired Engineering,
Harvard University,
Cambridge, MA 02115
Inspired Engineering,
Harvard University,
Cambridge, MA 02115
Search for other works by this author on:
L. J. Soslowsky
L. J. Soslowsky
McKay Orthopaedic Laboratory,
University of Pennsylvania,
Stemmler Hall, 3450 Hamilton Walk,
Philadelphia, PA 19104
e-mail: soslowsk@upenn.edu
University of Pennsylvania,
Stemmler Hall, 3450 Hamilton Walk,
Philadelphia, PA 19104
e-mail: soslowsk@upenn.edu
Search for other works by this author on:
K. A. Bonilla
McKay Orthopaedic Laboratory,
University of Pennsylvania,
Philadelphia, PA 19104
University of Pennsylvania,
Philadelphia, PA 19104
A. M. Pardes
McKay Orthopaedic Laboratory,
University of Pennsylvania,
Philadelphia, PA 19104
University of Pennsylvania,
Philadelphia, PA 19104
B. R. Freedman
McKay Orthopaedic Laboratory,
University of Pennsylvania,
Philadelphia, PA 19104;
University of Pennsylvania,
Philadelphia, PA 19104;
John A. Paulson School of Engineering
and Applied Sciences,
Harvard University,
Cambridge, MA 02138;
and Applied Sciences,
Harvard University,
Cambridge, MA 02138;
Wyss Institute for Biologically
Inspired Engineering,
Harvard University,
Cambridge, MA 02115
Inspired Engineering,
Harvard University,
Cambridge, MA 02115
L. J. Soslowsky
McKay Orthopaedic Laboratory,
University of Pennsylvania,
Stemmler Hall, 3450 Hamilton Walk,
Philadelphia, PA 19104
e-mail: soslowsk@upenn.edu
University of Pennsylvania,
Stemmler Hall, 3450 Hamilton Walk,
Philadelphia, PA 19104
e-mail: soslowsk@upenn.edu
1All authors contributed equally to this work.
2Corresponding author.
Manuscript received September 14, 2017; final manuscript received August 8, 2018; published online October 17, 2018. Assoc. Editor: Guy M. Genin.
J Biomech Eng. Jan 2019, 141(1): 011002 (8 pages)
Published Online: October 17, 2018
Article history
Received:
September 14, 2017
Revised:
August 8, 2018
Citation
Bonilla, K. A., Pardes, A. M., Freedman, B. R., and Soslowsky, L. J. (October 17, 2018). "Supraspinatus Tendons Have Different Mechanical Properties Across Sex." ASME. J Biomech Eng. January 2019; 141(1): 011002. https://doi.org/10.1115/1.4041321
Download citation file:
Get Email Alerts
Aged Tendons Exhibit Altered Mechanisms of Strain-Dependent Extracellular Matrix Remodeling
J Biomech Eng (July 2024)
Influence of Breath-Mimicking Ventilated Incubation on Three-Dimensional Bioprinted Respiratory Tissue Scaffolds
J Biomech Eng (September 2024)
Related Articles
Pregnancy and Lactation Impair Subchondral Bone Leading to Reduced Rat Supraspinatus Tendon-to-Bone Insertion Site Failure Properties
J Biomech Eng (November,2020)
Long Durations of Immobilization in the Rat Result in Enhanced Mechanical Properties of the Healing Supraspinatus Tendon Insertion Site
J Biomech Eng (June,2007)
Pre-Impact Lower Extremity Posture and Brake Pedal Force Predict Foot and Ankle Forces During an Automobile Collision
J Biomech Eng (December,2004)
A Lead Garment Structural Systemto Reduce Musculoskeletal Stress During Fluoroscopy
J. Med. Devices (December,2019)
Related Chapters
Age and Gender: Two Epidemiological Factors in Skiing and Snowboarding Injury
Skiing Trauma and Safety: Tenth Volume
Surface Analysis and Tools
Tribology of Mechanical Systems: A Guide to Present and Future Technologies
A New Load Application System for In Vitro Study of Ligamentous Injuries to the Human Knee Joint
Skiing Trauma and Safety: Tenth Volume