Cell migration is a highly regulated and complex cellular process to maintain proper homeostasis for various biological processes. Extracellular environment was identified as the main affecting factors determining the direction of cell crawling. It was observed experimentally that the cell prefers migrating to the area with denser or stiffer array of microposts. In this article, an integrated unidirectional cell crawling model was developed to investigate the spatiotemporal dynamics of unidirectional cell migration, which incorporates the dominating intracellular biochemical processes, biomechanical processes and the properties of extracellular micropost arrays. The interpost spacing and the stiffness of microposts are taken into account, respectively, to study the mechanism of unidirectional cell locomotion and the guidance of extracellular influence cues on the direction of unidirectional cell crawling. The model can explain adequately the unidirectional crawling phenomena observed in experiments such as “spatiotaxis” and “durotaxis,” which allows us to obtain further insights into cell migration.
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March 2015
Research-Article
Unidirectional Cell Crawling Model Guided by Extracellular Cues
Zhanjiang Wang,
Zhanjiang Wang
1
State Key Laboratory
of Mechanical Transmission,
e-mail: wangzhanjiang001@gmail.com
of Mechanical Transmission,
Chongqing University
,Chongqing 400030
, China
e-mail: wangzhanjiang001@gmail.com
1Corresponding author.
Search for other works by this author on:
Yuxu Geng
Yuxu Geng
State Key Laboratory
of Mechanical Transmission,
of Mechanical Transmission,
Chongqing University
,Chongqing 400030
, China
Search for other works by this author on:
Zhanjiang Wang
State Key Laboratory
of Mechanical Transmission,
e-mail: wangzhanjiang001@gmail.com
of Mechanical Transmission,
Chongqing University
,Chongqing 400030
, China
e-mail: wangzhanjiang001@gmail.com
Yuxu Geng
State Key Laboratory
of Mechanical Transmission,
of Mechanical Transmission,
Chongqing University
,Chongqing 400030
, China
1Corresponding author.
Manuscript received February 26, 2014; final manuscript received November 28, 2014; published online January 29, 2015. Assoc. Editor: Mohammad Mofrad.
J Biomech Eng. Mar 2015, 137(3): 031006 (8 pages)
Published Online: March 1, 2015
Article history
Received:
February 26, 2014
Revision Received:
November 28, 2014
Online:
January 29, 2015
Citation
Wang, Z., and Geng, Y. (March 1, 2015). "Unidirectional Cell Crawling Model Guided by Extracellular Cues." ASME. J Biomech Eng. March 2015; 137(3): 031006. https://doi.org/10.1115/1.4029301
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