Ischemic heart disease is a major health problem worldwide, and current therapies fail to address microrevascularization. Previously, our group demonstrated that the sustained release of novel engineered stromal cell-derived factor 1-α analogue (ESA) limits infarct spreading, collagen deposition, improves cardiac function by promoting angiogenesis in the region surrounding the infarct, and restores the tensile properties of infarcted myocardium. In this study, using a well-established rat model of ischemic cardiomyopathy, we describe a novel and innovative method for analyzing the viscoelastic properties of infarcted myocardium. Our results demonstrate that, compared with a saline control group, animals treated with ESA have significantly improved myocardial relaxation rates, while reducing the transition strain, leading to restoration of left ventricular mechanics.
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August 2014
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Bioengineered Stromal Cell-Derived Factor-1α Analogue Delivered as an Angiogenic Therapy Significantly Restores Viscoelastic Material Properties of Infarcted Cardiac Muscle
Alen Trubelja,
Alen Trubelja
Division of Cardiovascular Surgery,
Department of Surgery,
Department of Surgery,
University of Pennsylvania School of Medicine
,Philadelphia, PA 19104
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John W. MacArthur,
John W. MacArthur
Division of Cardiovascular Surgery,
Department of Surgery,
Department of Surgery,
University of Pennsylvania School of Medicine
,Philadelphia, PA 19104
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Joseph J. Sarver,
Joseph J. Sarver
School of Biomedical Engineering,
Science & Health Systems,
Science & Health Systems,
Drexel University
,Philadelphia, PA 19104
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Jeffrey E. Cohen,
Jeffrey E. Cohen
Department of Cardiothoracic Surgery,
Stanford University School of Medicine
,Stanford, CA 94305
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George Hung,
George Hung
Division of Cardiovascular Surgery,
Department of Surgery,
Department of Surgery,
University of Pennsylvania School of Medicine
,Philadelphia, PA 19104
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Yasuhiro Shudo,
Yasuhiro Shudo
Department of Cardiothoracic Surgery,
Stanford University School of Medicine
,Stanford, CA 94305
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Alexander S. Fairman,
Alexander S. Fairman
Division of Cardiovascular Surgery,
Department of Surgery,
Department of Surgery,
University of Pennsylvania School of Medicine
, Philadelphia, PA 19104
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Jay Patel,
Jay Patel
Department of Cardiothoracic Surgery,
Stanford University School of Medicine
,Stanford, CA 94305
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Bryan B. Edwards,
Bryan B. Edwards
Department of Cardiothoracic Surgery,
Stanford University School of Medicine
,Stanford, CA 94305
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Scott M. Damrauer,
Scott M. Damrauer
Division of Vascular Surgery,
Department of Surgery,
Department of Surgery,
University of Pennsylvania School of Medicine
,Philadelphia, PA 19104
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William Hiesinger,
William Hiesinger
Division of Cardiovascular Surgery,
Department of Surgery,
Department of Surgery,
University of Pennsylvania School of Medicine
,Philadelphia, PA 19104
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Pavan Atluri,
Pavan Atluri
Division of Cardiovascular Surgery,
Department of Surgery,
Department of Surgery,
University of Pennsylvania School of Medicine
,Philadelphia, PA 19104
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Y. Joseph Woo
Y. Joseph Woo
Department of Cardiothoracic Surgery,
e-mail: joswoo@stanford.edu
Stanford University School of Medicine
,Stanford, CA 94305
e-mail: joswoo@stanford.edu
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Alen Trubelja
Division of Cardiovascular Surgery,
Department of Surgery,
Department of Surgery,
University of Pennsylvania School of Medicine
,Philadelphia, PA 19104
John W. MacArthur
Division of Cardiovascular Surgery,
Department of Surgery,
Department of Surgery,
University of Pennsylvania School of Medicine
,Philadelphia, PA 19104
Joseph J. Sarver
School of Biomedical Engineering,
Science & Health Systems,
Science & Health Systems,
Drexel University
,Philadelphia, PA 19104
Jeffrey E. Cohen
Department of Cardiothoracic Surgery,
Stanford University School of Medicine
,Stanford, CA 94305
George Hung
Division of Cardiovascular Surgery,
Department of Surgery,
Department of Surgery,
University of Pennsylvania School of Medicine
,Philadelphia, PA 19104
Yasuhiro Shudo
Department of Cardiothoracic Surgery,
Stanford University School of Medicine
,Stanford, CA 94305
Alexander S. Fairman
Division of Cardiovascular Surgery,
Department of Surgery,
Department of Surgery,
University of Pennsylvania School of Medicine
, Philadelphia, PA 19104
Jay Patel
Department of Cardiothoracic Surgery,
Stanford University School of Medicine
,Stanford, CA 94305
Bryan B. Edwards
Department of Cardiothoracic Surgery,
Stanford University School of Medicine
,Stanford, CA 94305
Scott M. Damrauer
Division of Vascular Surgery,
Department of Surgery,
Department of Surgery,
University of Pennsylvania School of Medicine
,Philadelphia, PA 19104
William Hiesinger
Division of Cardiovascular Surgery,
Department of Surgery,
Department of Surgery,
University of Pennsylvania School of Medicine
,Philadelphia, PA 19104
Pavan Atluri
Division of Cardiovascular Surgery,
Department of Surgery,
Department of Surgery,
University of Pennsylvania School of Medicine
,Philadelphia, PA 19104
Y. Joseph Woo
Department of Cardiothoracic Surgery,
e-mail: joswoo@stanford.edu
Stanford University School of Medicine
,Stanford, CA 94305
e-mail: joswoo@stanford.edu
Manuscript received December 20, 2013; final manuscript received May 15, 2014; accepted manuscript posted May 23, 2014; published online June 2, 2014. Assoc. Editor: Hai-Chao Han.
J Biomech Eng. Aug 2014, 136(8): 084501 (5 pages)
Published Online: June 2, 2014
Article history
Received:
December 20, 2013
Revision Received:
May 15, 2014
Accepted:
May 23, 2014
Citation
Trubelja, A., MacArthur, J. W., Sarver, J. J., Cohen, J. E., Hung, G., Shudo, Y., Fairman, A. S., Patel, J., Edwards, B. B., Damrauer, S. M., Hiesinger, W., Atluri, P., and Joseph Woo, Y. (June 2, 2014). "Bioengineered Stromal Cell-Derived Factor-1α Analogue Delivered as an Angiogenic Therapy Significantly Restores Viscoelastic Material Properties of Infarcted Cardiac Muscle." ASME. J Biomech Eng. August 2014; 136(8): 084501. https://doi.org/10.1115/1.4027731
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