Computational fluid dynamics (CFD) opens up multiple opportunities to investigate the hemodynamics of the human vascular system. However, due to numerous assumptions the acceptance of CFD among physicians is still limited in practice and validation through comparison is mandatory. Time-dependent quantitative phase-contrast magnetic resonance imaging PC-MRI measurements in a healthy volunteer and two intracranial aneurysms were carried out at 3 and 7 Tesla. Based on the acquired images, three-dimensional (3D) models of the aneurysms were reconstructed and used for the numerical simulations. Flow information from the MR measurements were applied as boundary conditions. The four-dimensional (4D) velocity fields obtained by CFD and MRI were qualitatively as well as quantitatively compared including cut planes and vector analyses. For all cases a high similarity of the velocity patterns was observed. Additionally, the quantitative analysis revealed a good agreement between CFD and MRI. Deviations were caused by minor differences between the reconstructed vessel models and the actual lumen. The comparisons between diastole and systole indicate that relative differences between MRI and CFD are intensified with increasing velocity. The findings of this study lead to the conclusion that CFD and MRI agree well in predicting intracranial velocities when realistic geometries and boundary conditions are provided. Due to the considerably higher temporal and spatial resolution of CFD compared to MRI, complex flow patterns can be further investigated in order to evaluate their role with respect to aneurysm formation or rupture. Nevertheless, special care is required regarding the vessel reconstruction since the geometry has a major impact on the subsequent numerical results.
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April 2014
Research-Article
Cerebral Blood Flow in a Healthy Circle of Willis and Two Intracranial Aneurysms: Computational Fluid Dynamics Versus Four-Dimensional Phase-Contrast Magnetic Resonance Imaging
Philipp Berg,
Philipp Berg
Department of Fluid Dynamics
and Technical Flows,
Universitaetsplatz 2,
e-mail: Philipp.Berg@ovgu.de
and Technical Flows,
University of Magdeburg
,Universitaetsplatz 2,
Magdeburg 39106
, Germany
e-mail: Philipp.Berg@ovgu.de
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Daniel Stucht,
Daniel Stucht
Department of Biomedical Magnetic Resonance,
Leipziger Straße 44,
e-mail: Daniel.Stucht@ovgu.de
University of Magdeburg
,Leipziger Straße 44,
Magdeburg 39120
, Germany
e-mail: Daniel.Stucht@ovgu.de
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Gábor Janiga,
Gábor Janiga
Department of Fluid Dynamics
and Technical Flows,
Universitaetsplatz 2,
e-mail: Gabor.Janiga@ovgu.de
and Technical Flows,
University of Magdeburg
,Universitaetsplatz 2,
Magdeburg 39106
, Germany
e-mail: Gabor.Janiga@ovgu.de
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Oliver Beuing,
Oliver Beuing
Department of Neuroradiology,
Leipziger Straße 44,
e-mail: Oliver.Beuing@med.ovgu.de
University Hospital of Magdeburg
,Leipziger Straße 44,
Magdeburg 39120
, Germany
e-mail: Oliver.Beuing@med.ovgu.de
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Oliver Speck,
Brenneckestraße 6,
e-mail: Oliver.Speck@ovgu.de
Oliver Speck
Department of Biomedical Magnetic Resonance,
Leipziger Straße 44,
University of Magdeburg
,Leipziger Straße 44,
Magdeburg 39120
, Germany
Leibniz Institute for Neurobiology
,Brenneckestraße 6,
Magdeburg 39118
, Germany
e-mail: Oliver.Speck@ovgu.de
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Dominique Thévenin
Dominique Thévenin
Department of Fluid Dynamics
and Technical Flows,
Universitaetsplatz 2,
e-mail: Dominique.Thevenin@ovgu.de
and Technical Flows,
University of Magdeburg
,Universitaetsplatz 2,
Magdeburg 39106
, Germany
e-mail: Dominique.Thevenin@ovgu.de
Search for other works by this author on:
Philipp Berg
Department of Fluid Dynamics
and Technical Flows,
Universitaetsplatz 2,
e-mail: Philipp.Berg@ovgu.de
and Technical Flows,
University of Magdeburg
,Universitaetsplatz 2,
Magdeburg 39106
, Germany
e-mail: Philipp.Berg@ovgu.de
Daniel Stucht
Department of Biomedical Magnetic Resonance,
Leipziger Straße 44,
e-mail: Daniel.Stucht@ovgu.de
University of Magdeburg
,Leipziger Straße 44,
Magdeburg 39120
, Germany
e-mail: Daniel.Stucht@ovgu.de
Gábor Janiga
Department of Fluid Dynamics
and Technical Flows,
Universitaetsplatz 2,
e-mail: Gabor.Janiga@ovgu.de
and Technical Flows,
University of Magdeburg
,Universitaetsplatz 2,
Magdeburg 39106
, Germany
e-mail: Gabor.Janiga@ovgu.de
Oliver Beuing
Department of Neuroradiology,
Leipziger Straße 44,
e-mail: Oliver.Beuing@med.ovgu.de
University Hospital of Magdeburg
,Leipziger Straße 44,
Magdeburg 39120
, Germany
e-mail: Oliver.Beuing@med.ovgu.de
Oliver Speck
Department of Biomedical Magnetic Resonance,
Leipziger Straße 44,
University of Magdeburg
,Leipziger Straße 44,
Magdeburg 39120
, Germany
Leibniz Institute for Neurobiology
,Brenneckestraße 6,
Magdeburg 39118
, Germany
e-mail: Oliver.Speck@ovgu.de
Dominique Thévenin
Department of Fluid Dynamics
and Technical Flows,
Universitaetsplatz 2,
e-mail: Dominique.Thevenin@ovgu.de
and Technical Flows,
University of Magdeburg
,Universitaetsplatz 2,
Magdeburg 39106
, Germany
e-mail: Dominique.Thevenin@ovgu.de
Contributed by the Bioengineering Division of ASME for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING. Manuscript received May 30, 2013; final manuscript received November 21, 2013; accepted manuscript posted November 27, 2013; published online March 24, 2014. Assoc. Editor: Dalin Tang.
J Biomech Eng. Apr 2014, 136(4): 041003 (9 pages)
Published Online: March 24, 2014
Article history
Received:
May 30, 2013
Revision Received:
November 21, 2013
Accepted:
November 27, 2013
Citation
Berg, P., Stucht, D., Janiga, G., Beuing, O., Speck, O., and Thévenin, D. (March 24, 2014). "Cerebral Blood Flow in a Healthy Circle of Willis and Two Intracranial Aneurysms: Computational Fluid Dynamics Versus Four-Dimensional Phase-Contrast Magnetic Resonance Imaging." ASME. J Biomech Eng. April 2014; 136(4): 041003. https://doi.org/10.1115/1.4026108
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