Polyvinyl alcohol (PVA) cryogel covered stents may reduce complications from thrombosis and restenosis by decreasing tissue prolapse. Finite element analysis was employed to evaluate the effects of PVA cryogel layers of varying thickness on tissue prolapse and artery wall stress for two common stent geometries and two vessel diameters. Additionally, several PVA cryogel covered stents were fabricated and imaged with an environmental scanning electron microscope. Finite element results showed that covered stents reduced tissue prolapse up to 13% and artery wall stress up to 29% with the size of the reduction depending on the stent geometry, vessel diameter, and PVA cryogel layer thickness. Environmental scanning electron microscope images of expanded covered stents showed the PVA cryogel to completely cover the area between struts without gaps or tears. Overall, this work provides both computational and experimental evidence for the use of PVA cryogels in covered stents.
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e-mail: jason.weaver@gatech.edu
e-mail: david.ku@me.gatech.edu
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February 2012
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A Study on the Effects of Covered Stents on Tissue Prolapse
Jason D. Weaver,
Jason D. Weaver
Wallace H. Coulter Department of Biomedical Engineering,
e-mail: jason.weaver@gatech.edu
Georgia Institute of Technology and Emory University
, 315 Ferst Dr., Room 2119, Atlanta, GA 30332
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D. N. Ku
D. N. Ku
George W. Woodruff School of Mechanical Engineering,
e-mail: david.ku@me.gatech.edu
Georgia Institute of Technology,
315 Ferst Dr., Room 2307, Atlanta, GA 30332
Search for other works by this author on:
Jason D. Weaver
Wallace H. Coulter Department of Biomedical Engineering,
Georgia Institute of Technology and Emory University
, 315 Ferst Dr., Room 2119, Atlanta, GA 30332e-mail: jason.weaver@gatech.edu
D. N. Ku
George W. Woodruff School of Mechanical Engineering,
Georgia Institute of Technology,
315 Ferst Dr., Room 2307, Atlanta, GA 30332e-mail: david.ku@me.gatech.edu
J Biomech Eng. Feb 2012, 134(2): 024505 (6 pages)
Published Online: March 19, 2012
Article history
Received:
October 31, 2011
Revised:
February 14, 2012
Posted:
February 24, 2012
Published:
March 14, 2012
Online:
March 19, 2012
Citation
Weaver, J. D., and Ku, D. N. (March 19, 2012). "A Study on the Effects of Covered Stents on Tissue Prolapse." ASME. J Biomech Eng. February 2012; 134(2): 024505. https://doi.org/10.1115/1.4006199
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