Atrial fibrillation (AF) is a cardiac arrhythmia that highly increases the risk of stroke and is associated with significant but still unexplored changes in the mechanical behavior of the tissue. Planar biaxial tests were performed on tissue specimens from pigs at the healthy stage and after ventricular tachypacing (VTP), a procedure applied to reproduce the relevant features of AF. The local arrangement of the fiber bundles in the tissue was investigated on specimens from rabbit atria by means of circularly polarized light. Based on this, mechanical data were fitted to two anisotropic constitutive relationships, including a four-parameter Fung-type model and a microstructurally-motivated model. Accounting for the fiber-induced anisotropy brought average R2 = 0.807 for the microstructurally-motivated model and average R2 = 0.949 for the Fung model. Validation of the fitted constitutive relationships was performed by means of FEM simulations coupled to FORTRAN routines. The performances of the two material models in predicting the second Piola-Kirchhoff stress were comparable, with average errors <3.1%. However, the Fung model outperformed the other in the prediction of the Green-Lagrange strain, with 9.2% maximum average error. To increase model generality, a proper averaging procedure accounting for nonlinearities was used to obtain average material parameters. In general, a stiffer behavior after VTP was noted.
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e-mail: cbellini@ucalgary.ca
e-mail: edimarti@ucalgary.ca
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February 2012
Research Papers
A Mechanical Characterization of the Porcine Atria at the Healthy Stage and After Ventricular Tachypacing
Chiara Bellini,
Chiara Bellini
Graduate Research Assistant
Student Mem.ASME
Graduate Program in Biomedical Engineering,
e-mail: cbellini@ucalgary.ca
The University of Calgary
, Calgary, Alberta T2N1N4, Canada
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Elena S. Di Martino
Elena S. Di Martino
Professor
Mem. ASME
Department of Civil Engineering,Center for Bioengineering Research and Education,
e-mail: edimarti@ucalgary.ca
The University of Calgary
, Calgary, Alberta T2N1N4, Canada
Search for other works by this author on:
Chiara Bellini
Graduate Research Assistant
Student Mem.ASME
Graduate Program in Biomedical Engineering,
The University of Calgary
, Calgary, Alberta T2N1N4, Canada
e-mail: cbellini@ucalgary.ca
Elena S. Di Martino
Professor
Mem. ASME
Department of Civil Engineering,Center for Bioengineering Research and Education,
The University of Calgary
, Calgary, Alberta T2N1N4, Canada
e-mail: edimarti@ucalgary.ca
J Biomech Eng. Feb 2012, 134(2): 021008 (14 pages)
Published Online: March 19, 2012
Article history
Received:
January 20, 2012
Revised:
January 24, 2012
Posted:
February 13, 2012
Published:
March 14, 2012
Online:
March 19, 2012
Citation
Bellini, C., and Di Martino, E. S. (March 19, 2012). "A Mechanical Characterization of the Porcine Atria at the Healthy Stage and After Ventricular Tachypacing." ASME. J Biomech Eng. February 2012; 134(2): 021008. https://doi.org/10.1115/1.4006026
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