Mechanical stimulation has been shown to dramatically improve mechanical and functional properties of gel-derived tissue engineered blood vessels (TEBVs). Adjusting factors such as cell source, type of extracellular matrix, cross-linking, magnitude, frequency, and time course of mechanical stimuli (among many other factors) make interpretation of experimental results challenging. Interpretation of data from such multifactor experiments requires modeling. We present a modeling framework and simulations for mechanically mediated growth, remodeling, plasticity, and damage of gel-derived TEBVs that merge ideas from classical plasticity, volumetric growth, and continuum damage mechanics. Our results are compared with published data and suggest that this model framework can predict the evolution of geometry and material behavior under common experimental loading scenarios.
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e-mail: rudy.gleason@me.gatech.edu
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October 2009
Research Papers
A Phenomenological Model for Mechanically Mediated Growth, Remodeling, Damage, and Plasticity of Gel-Derived Tissue Engineered Blood Vessels
Julia Raykin,
Julia Raykin
Department of Biomedical Engineering,
Georgia Institute of Technology
, Atlanta, GA 30332
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Alexander I. Rachev,
Alexander I. Rachev
School of Mechanical Engineering,
Georgia Institute of Technology
, Atlanta, GA 30332
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Rudolph L. Gleason, Jr.
Rudolph L. Gleason, Jr.
Department of Biomedical Engineering, School of Mechanical Engineering, and Petite Institute for Bioengineering and Bioscience,
e-mail: rudy.gleason@me.gatech.edu
Georgia Institute of Technology
, Atlanta, GA 30332
Search for other works by this author on:
Julia Raykin
Department of Biomedical Engineering,
Georgia Institute of Technology
, Atlanta, GA 30332
Alexander I. Rachev
School of Mechanical Engineering,
Georgia Institute of Technology
, Atlanta, GA 30332
Rudolph L. Gleason, Jr.
Department of Biomedical Engineering, School of Mechanical Engineering, and Petite Institute for Bioengineering and Bioscience,
Georgia Institute of Technology
, Atlanta, GA 30332e-mail: rudy.gleason@me.gatech.edu
J Biomech Eng. Oct 2009, 131(10): 101016 (12 pages)
Published Online: October 13, 2009
Article history
Received:
January 15, 2009
Revised:
August 19, 2009
Posted:
September 1, 2009
Published:
October 13, 2009
Citation
Raykin, J., Rachev, A. I., and Gleason, R. L., Jr. (October 13, 2009). "A Phenomenological Model for Mechanically Mediated Growth, Remodeling, Damage, and Plasticity of Gel-Derived Tissue Engineered Blood Vessels." ASME. J Biomech Eng. October 2009; 131(10): 101016. https://doi.org/10.1115/1.4000124
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