Rapid cooling of the brain in the first minutes following the onset of cerebral ischemia is a potentially attractive preservation method. This computer modeling study was undertaken to examine brain-cooling profiles in response to various external cooling methods and protocols, in order to guide the development of cooling devices suitable for deployment on emergency medical vehicles. The criterion of successful cooling is taken to be the attainment of a 33°C average brain temperature within 30 min of treatment. The transient cooling of an anatomically correct realistic 3-D head and neck with realistically varying local tissue properties was numerically simulated using the finite-element method (FEM). The simulations performed in this study consider ice packs applied to head and neck as well as using a head-cooling helmet. However, it was found that neither of these cooling approaches satisfies the 33°C temperature within 30 min. This central conclusion of insubstantial cooling is supported by the modest enhancements reported in experimental investigations of externally applied cooling. The key problem is overcoming the protective effect of warm blood perfusion, which reaches the brain via the uncooled carotid arterial supply and effectively blocks the external cooling wave from advancing to the core of the brain. The results show that substantial cooling could be achieved in conjunction with neck cooling if the blood speed in the carotid artery is reduced from normal by a factor of 10. The results suggest that additional cooling means should be explored, such as cooling of other pertinent parts of the human anatomy.

Issue Section:
Technical Papers
Keywords:
brain models, physiological models, cooling, biothermics, patient treatment, finite element analysis
Topics:
Biological tissues, Cooling, Temperature, Ice, Brain, Blood
1.
Ku
,
Y.-T.
,
Montgomery
,
L. D.
, and
Webbon
,
B. W.
,
1996
, “
Hemodynamic and Thermal Responses to Head and Neck Cooling in Men and Women
,”
Am. J. Phys. Med. Rehabil.
,
75
(
6
), pp.
443
–
450
.
2.
Orr, C. S., and Eberhart, R. C., 1998, “Bioheat Transfer in Blood Perfused Tissues and Clinical Application of Hypothermia,” Chapter 1 in Annual Review of Heat Transfer, ed.: C. L. Tien, Begell House, New York, pp. 1–78.
3.
Olsen, R. W., 1985, “Temperature Profiles in the Head and Other Tissues of the Macaque Rhesus Monkey Subjected to Surface and/or Core Cooling,” Ph.D. Dissertation, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas.
4.
Olsen
,
R. W.
,
Hayes
,
L. J.
,
Wisler
,
E. H.
,
Nikaidoh
,
H.
, and
Eberhart
,
R. C.
,
1985
, “
Influence of Hypothermia and Circulatory Arrest on Cerebral Temperature Distributions
,”
ASME J. Biomech. Eng.
,
107
, pp.
354
–
360
.
5.
Vietla, S., 1995, “The Influence of Hypothermia and Tissue Perfusion on Temperature Distribution in Simulated Intracranial Surgery,” M.Sc. thesis, University of Texas Southwestern Medical Center at Dallas, Dallas, TX.
6.
Pennes
,
H. H.
,
1948
, “
Analysis of Tissue and Arterial Blood Temperatures in the Resting Forearm
,”
J. Appl. Physiol.
,
1
, pp.
93
–
122
.
7.
Huebner, K. H., Thorton, E. A., and Byrom, T. G., 1995, The Finite Element Method for Engineers, John Wiley and Sons, New York, NY, 3rd edition.
8.
Balay, S., Gropp, W. D., McInnes, L. S., and Smith, B. F., 1999, “PETSc 2.0 Users Manual,” Technical Report ANL-95/11—Revision 2.0.24, Argonne National Laboratory.
9.
Dennis
,
B. H.
, and
Dulikravich
,
G. S.
,
1999
, “
Simultaneous Determination of Temperatures, Heat Fluxes, Deformations, and Tractions on Inaccessible Boundaries
,”
ASME J. Heat Transfer
,
121
, pp.
537
–
545
.
10.
Dennis, B. H., and Dulikravich, G. S., 2000, “Determination of Unsteady Container Temperatures During Freezing of Three-Dimensional Organs With Constrained Thermal Stresses,” In: Internat. Symposium on Inverse Problems in Engineering Mechanics—ISIP’2k, eds: M. Tanaka and G. S. Dulikravich, Nagano, Japan, March 7–10, 2000, Elsevier Science Ltd, Amsterdam, pp. 139–148.
11.
Dennis, B. H., Dulikravich, G. S., and Rabin, Y., 2000, “Optimization of Organ Freezing Protocols With Specified Allowable Thermal Stress Levels,” ASME IMECE 2000, Orlando, FL, Nov. 5–10, 2000, HTD-Vol. 368/BED-Vol. 47, pp. 33–48.
12.
Proceedings of First Users Conference of the National Library of Medicine’s Visible Human Project, October 7–8, 1996, National Institute of Health, Bethesda, MD.
13.
Sachse, F., Werner, C., Mu¨ller, M., and Meyer-Waarden, K., 1996, “Preprocessing of the Visible Man Dataset for the Generation of Macroscopic Anatomical Models,” Proc. First Users Conference of the National Library of Medicine’s Visible Human Project, October 7–8, 1996, National Institute of Health, Bethesda, MD.
14.
Sachse, F., Werner, C., Mu¨ller, M., and Meyer-Waarden, K., 1996, “Segmentation and Tissue-Classification of the Visible Man Dataset Using the Computertomographic Scans and the Thin-Section Photos,” Proc. First Users Conference of the National Library of Medicine’s Visible Human Project, October 7–8, 1996, National Institute of Health, Bethesda, MD.
15.
Shitzer, A., and Eberhart, R. C. (eds.), 1985, Heat Transfer in Medicine and Biology: Analysis and Applications, Volume II, Appendix II, Plenum Press, New York.
16.
Shitzer, A., and Eberhart, R. C. (eds.), 1985, Heat Transfer in Medicine and Biology, Analysis and Applications, Volume 1, Plenum Press, New York, Chap. 12, pp. 279–283.
17.
Bowman
,
H. F.
,
Cravalho
,
E. G.
, and
Woods
,
M.
,
1975
, “
Theory, Measurement, and Application of Thermal Properties of Biomaterials
,”
Annu. Rev. Biophys. Bioeng.
,
4
, pp.
43
–
80
.
18.
Valvano
,
J. W.
,
Cochran
,
J. R.
, and
Diller
,
K. R.
,
1985
, “
Thermal Conductivity and Diffusivity of Biomaterials Measured With Self-Heated Thermistors
,”
International Journal of Thermophysics
,
6
(
3
), pp.
301
–
310
.
19.
Corbett
,
R. J. T.
, and
Laptook
,
A.
,
1988
, “
Failure of Localized Head Cooling to Reduce Brain Temperature in Adult Humans
,”
NeuroReport
,
9
, pp.
2721
–
2725
.
20.
Bernard
,
S. A.
,
Jones
,
B. M.
, and
Horne
,
M. K.
,
1997
, “
A Clinical Trial of Induced Hypothermia in Comatose Survivors of Prehospital Cardiac Arrest
,”
Ann. Emerg. Med.
,
30
, pp.
146
–
153
.
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