A network thermodynamic model has been devised to describe the coupled movement of water and a permeable additive within a kidney during perfusion under the combined action of diffusive, hydrodynamic, and mechanical processes. The model has been validated by simulating perfusions with Me2SO, glycerol, and sucrose and comparing predicted weight and vascular resistance with experimental results obtained by Pegg (1993). The flows of CPA, water, colloid, and cellular impermeants are governed by a combination of the individual osmotic potential and pressure differences between compartments of the kidney, the viscoelastic behavior of the tissue, and the momentum transferred between the flows. The model developed in this study presents an analytical tool for understanding the dynamics of the perfused kidney system and for modifying perfusion protocols to minimize the changes in cell volume, internal pressure build-up, and increases in vascular resistance that currently present barriers to the successful perfusion of organs.
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December 1999
Technical Papers
A Network Thermodynamic Model of Kidney Perfusion With a Cryoprotective Agent
C. A. Lachenbruch,
C. A. Lachenbruch
Biomedical Engineering Program, Department of Mechanical Engineering, The University of Texas at Austin, Austin, TX 78712
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K. R. Diller
K. R. Diller
Biomedical Engineering Program, Department of Mechanical Engineering, The University of Texas at Austin, Austin, TX 78712
e-mail: kdiller@mail.utexas.edu
Search for other works by this author on:
C. A. Lachenbruch
Biomedical Engineering Program, Department of Mechanical Engineering, The University of Texas at Austin, Austin, TX 78712
K. R. Diller
Biomedical Engineering Program, Department of Mechanical Engineering, The University of Texas at Austin, Austin, TX 78712
e-mail: kdiller@mail.utexas.edu
J Biomech Eng. Dec 1999, 121(6): 574-583 (10 pages)
Published Online: December 1, 1999
Article history
Received:
February 14, 1998
Revised:
June 6, 1999
Online:
October 30, 2007
Citation
Lachenbruch, C. A., and Diller, K. R. (December 1, 1999). "A Network Thermodynamic Model of Kidney Perfusion With a Cryoprotective Agent." ASME. J Biomech Eng. December 1999; 121(6): 574–583. https://doi.org/10.1115/1.2800856
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