We present data from isothermal free-shrinkage tests (i.e., performed in the absence of mechanical loads) wherein bovine chordae tendineae were subjected to temperatures from 65 to 85°C for 120 to 1200 s. These data reveal four new insights into heat-induced denaturation of a collagenous tissue. First, a characteristic time for the free shrinkage appears to exhibit an Arrhenius-type relationship with temperature. Second, scaling the actual heating time via the characteristic time results in a single correlation between free shrinkage and the duration of heating; this correlation suggests a time-temperature equivalence. Third, it is the cumulative, not current, heating time that governs the free shrinkage. And fourth, heat-induced free shrinkage is partially recovered when the tissue is returned to 37°C, this recovery also being time-dependent. Although these findings will help guide future experimentation and constitutive modeling, as well as the design of new heat-based clinical therapies, there is a pressing need to collect additional isothermal data, particularly in the presence of well-defined mechanical loads.
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November 1997
Technical Papers
Heat-Induced Changes in the Mechanics of a Collagenous Tissue: Isothermal Free Shrinkage
S. S. Chen,
S. S. Chen
Department of Mechanical Engineering, The University of Maryland, Baltimore, MD 21250
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N. T. Wright,
N. T. Wright
Department of Mechanical Engineering, The University of Maryland, Baltimore, MD 21250
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J. D. Humphrey
J. D. Humphrey
Department of Mechanical Engineering, The University of Maryland, Baltimore, MD 21250
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S. S. Chen
Department of Mechanical Engineering, The University of Maryland, Baltimore, MD 21250
N. T. Wright
Department of Mechanical Engineering, The University of Maryland, Baltimore, MD 21250
J. D. Humphrey
Department of Mechanical Engineering, The University of Maryland, Baltimore, MD 21250
J Biomech Eng. Nov 1997, 119(4): 372-378 (7 pages)
Published Online: November 1, 1997
Article history
Received:
February 7, 1996
Revised:
December 17, 1996
Online:
October 30, 2007
Citation
Chen, S. S., Wright, N. T., and Humphrey, J. D. (November 1, 1997). "Heat-Induced Changes in the Mechanics of a Collagenous Tissue: Isothermal Free Shrinkage." ASME. J Biomech Eng. November 1997; 119(4): 372–378. https://doi.org/10.1115/1.2798281
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