Recent explorations of knee biomechanics have benefited from computational modeling, specifically leveraging advancements in finite element analysis and rigid body dynamics of joint and tissue mechanics. A large number of models have emerged with different levels of fidelity in anatomical and mechanical representation. Adapted modeling and simulation processes vary widely, based on justifiable choices in relation to anticipated use of the model. However, there are situations where modelers' decisions seem to be subjective, arbitrary, and difficult to rationalize. Regardless of the basis, these decisions form the “art” of modeling, which impact the conclusions of simulation-based studies on knee function. These decisions may also hinder the reproducibility of models and simulations, impeding their broader use in areas such as clinical decision making and personalized medicine. This document summarizes an ongoing project that aims to capture the modeling and simulation workflow in its entirety—operation procedures, deviations, models, by-products of modeling, simulation results, and comparative evaluations of case studies and applications. The ultimate goal of the project is to delineate the art of a cohort of knee modeling teams through a publicly accessible, transparent approach and begin to unravel the complex array of factors that may lead to a lack of reproducibility. This manuscript outlines our approach along with progress made so far. Potential implications on reproducibility, on science, engineering, and training of modeling and simulation, on modeling standards, and on regulatory affairs are also noted.
Skip Nav Destination
Article navigation
July 2019
Research-Article
Deciphering the “Art” in Modeling and Simulation of the Knee Joint: Overall Strategy
Ahmet Erdemir,
Ahmet Erdemir
Department of Biomedical Engineering
and Computational Biomodeling (CoBi) Core,
Lerner Research Institute,
Cleveland Clinic,
9500 Euclid Avenue (ND20),
Cleveland, OH 44195
e-mail: erdemira@ccf.org
and Computational Biomodeling (CoBi) Core,
Lerner Research Institute,
Cleveland Clinic,
9500 Euclid Avenue (ND20),
Cleveland, OH 44195
e-mail: erdemira@ccf.org
1Corresponding author.
Search for other works by this author on:
Thor F. Besier,
Thor F. Besier
Department of Engineering Science,
Auckland Bioengineering Institute,
University of Auckland,
Auckland 1010, New Zealand
Auckland Bioengineering Institute,
University of Auckland,
Auckland 1010, New Zealand
Search for other works by this author on:
Jason P. Halloran,
Jason P. Halloran
Department of Mechanical Engineering,
Center for Human Machine Systems,
Cleveland State University,
Cleveland, OH 44115
Center for Human Machine Systems,
Cleveland State University,
Cleveland, OH 44115
Search for other works by this author on:
Carl W. Imhauser,
Carl W. Imhauser
Department of Biomechanics,
Hospital for Special Surgery,
New York, NY 10021
Hospital for Special Surgery,
New York, NY 10021
Search for other works by this author on:
Peter J. Laz,
Peter J. Laz
Department of Mechanical and
Materials Engineering,
Center for Orthopaedic Biomechanics,
University of Denver,
Denver, CO 80210
Materials Engineering,
Center for Orthopaedic Biomechanics,
University of Denver,
Denver, CO 80210
Search for other works by this author on:
Tina M. Morrison,
Tina M. Morrison
Division of Applied Mechanics,
Office of Science and Engineering Laboratories,
Center for Devices and Radiological Health,
Food and Drug Administration,
Silver Spring, MD 20993
Office of Science and Engineering Laboratories,
Center for Devices and Radiological Health,
Food and Drug Administration,
Silver Spring, MD 20993
Search for other works by this author on:
Kevin B. Shelburne
Kevin B. Shelburne
Department of Mechanical and
Materials Engineering,
Center for Orthopaedic Biomechanics,
University of Denver,
Denver, CO 80210
Materials Engineering,
Center for Orthopaedic Biomechanics,
University of Denver,
Denver, CO 80210
Search for other works by this author on:
Ahmet Erdemir
Department of Biomedical Engineering
and Computational Biomodeling (CoBi) Core,
Lerner Research Institute,
Cleveland Clinic,
9500 Euclid Avenue (ND20),
Cleveland, OH 44195
e-mail: erdemira@ccf.org
and Computational Biomodeling (CoBi) Core,
Lerner Research Institute,
Cleveland Clinic,
9500 Euclid Avenue (ND20),
Cleveland, OH 44195
e-mail: erdemira@ccf.org
Thor F. Besier
Department of Engineering Science,
Auckland Bioengineering Institute,
University of Auckland,
Auckland 1010, New Zealand
Auckland Bioengineering Institute,
University of Auckland,
Auckland 1010, New Zealand
Jason P. Halloran
Department of Mechanical Engineering,
Center for Human Machine Systems,
Cleveland State University,
Cleveland, OH 44115
Center for Human Machine Systems,
Cleveland State University,
Cleveland, OH 44115
Carl W. Imhauser
Department of Biomechanics,
Hospital for Special Surgery,
New York, NY 10021
Hospital for Special Surgery,
New York, NY 10021
Peter J. Laz
Department of Mechanical and
Materials Engineering,
Center for Orthopaedic Biomechanics,
University of Denver,
Denver, CO 80210
Materials Engineering,
Center for Orthopaedic Biomechanics,
University of Denver,
Denver, CO 80210
Tina M. Morrison
Division of Applied Mechanics,
Office of Science and Engineering Laboratories,
Center for Devices and Radiological Health,
Food and Drug Administration,
Silver Spring, MD 20993
Office of Science and Engineering Laboratories,
Center for Devices and Radiological Health,
Food and Drug Administration,
Silver Spring, MD 20993
Kevin B. Shelburne
Department of Mechanical and
Materials Engineering,
Center for Orthopaedic Biomechanics,
University of Denver,
Denver, CO 80210
Materials Engineering,
Center for Orthopaedic Biomechanics,
University of Denver,
Denver, CO 80210
1Corresponding author.
Manuscript received December 4, 2018; final manuscript received March 26, 2019; published online June 5, 2019. Editor: Beth A. Winkelstein.This work is in part a work of the U.S. Government. ASME disclaims all interest in the U.S. Government's contributions.
J Biomech Eng. Jul 2019, 141(7): 071002 (10 pages)
Published Online: June 5, 2019
Article history
Received:
December 4, 2018
Revised:
March 26, 2019
Citation
Erdemir, A., Besier, T. F., Halloran, J. P., Imhauser, C. W., Laz, P. J., Morrison, T. M., and Shelburne, K. B. (June 5, 2019). "Deciphering the “Art” in Modeling and Simulation of the Knee Joint: Overall Strategy." ASME. J Biomech Eng. July 2019; 141(7): 071002. https://doi.org/10.1115/1.4043346
Download citation file:
Get Email Alerts
Cited By
Related Articles
Computationally Efficient Magnetic Resonance Imaging Based Surface Contact Modeling as a Tool to Evaluate Joint Injuries and Outcomes of Surgical Interventions Compared to Finite Element Modeling
J Biomech Eng (April,2014)
Computational Modeling to Predict Mechanical Function of Joints: Application to the Lower Leg With Simulation of Two Cadaver Studies
J Biomech Eng (December,2007)
Articular Joint Mechanics With Biphasic Cartilage Layers Under Dynamic Loading
J Biomech Eng (February,1998)
Biomechanics of Diarthrodial Joints: A Review of Twenty Years of Progress
J Biomech Eng (November,1993)
Related Proceedings Papers
Related Chapters
The Effect of Anterior Cruciate Ligament Injury on Tibiofemoral Joint Biomechanics: Under Draw Load
International Conference on Mechanical Engineering and Technology (ICMET-London 2011)
Industrially-Relevant Multiscale Modeling of Hydrogen Assisted Degradation
International Hydrogen Conference (IHC 2012): Hydrogen-Materials Interactions
Numerical Simulation of Internal Flow for Nozzle on Gasoline Direct Injection Engine
International Conference on Mechanical and Electrical Technology, 3rd, (ICMET-China 2011), Volumes 1–3