Puncture testing has been applied in several studies for the mechanical characterization of human fetal membrane (FM) tissue, and significant knowledge has been gained from these investigations. When comparing results of mechanical testing (puncture, inflation, and uniaxial tension), we have observed discrepancies in the rupture sequence of FM tissue and significant differences in the deformation behavior. This study was undertaken to clarify these discrepancies. Puncture experiments on FM samples were performed to reproduce previous findings, and numerical simulations were carried out to rationalize particular aspects of membrane failure. The results demonstrate that both rupture sequence and resistance to deformation depend on the samples' fixation. Soft fixation leads to slippage in the clamping, which reduces mechanical loading of the amnion layer and results in chorion rupturing first. Conversely, the stiffer, stronger, and less extensible amnion layer fails first if tight fixation is used. The results provide a novel insight into the interpretation of ex vivo testing as well as in vivo membrane rupture.
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e-mail: buerzle@imes.mavt.ethz.ch
e-mail: mazza@imes.mavt.ethz.ch
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November 2014
Research-Article
About Puncture Testing Applied for Mechanical Characterization of Fetal Membranes
Wilfried Bürzle,
e-mail: buerzle@imes.mavt.ethz.ch
Wilfried Bürzle
Department of Mechanical
and Process Engineering,
and Process Engineering,
ETH Zurich
,Zurich 8092
, Switzerland
Institute for Mechanical Systems
,Tannenstrasse 3, CLA H 23.2
,Zurich 8092
, Switzerland
e-mail: buerzle@imes.mavt.ethz.ch
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Edoardo Mazza,
e-mail: mazza@imes.mavt.ethz.ch
Edoardo Mazza
1
Department of Mechanical
and Process Engineering,
and Process Engineering,
ETH Zurich
,Zurich 8092
, Switzerland
Institute for Mechanical Systems
,Leonhardstrasse 21, LEE N 210
,Zurich 8092
, Switzerland
e-mail: mazza@imes.mavt.ethz.ch
1Corresponding author.
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John J. Moore
John J. Moore
Division of Neonatology,
Case Western Reserve
e-mail: Jmoore@metrohealth.org
Case Western Reserve
University School of Medicine
,2500 MetroHealth Drive
,Cleveland, OH 44109
e-mail: Jmoore@metrohealth.org
Search for other works by this author on:
Wilfried Bürzle
Department of Mechanical
and Process Engineering,
and Process Engineering,
ETH Zurich
,Zurich 8092
, Switzerland
Institute for Mechanical Systems
,Tannenstrasse 3, CLA H 23.2
,Zurich 8092
, Switzerland
e-mail: buerzle@imes.mavt.ethz.ch
Edoardo Mazza
Department of Mechanical
and Process Engineering,
and Process Engineering,
ETH Zurich
,Zurich 8092
, Switzerland
Institute for Mechanical Systems
,Leonhardstrasse 21, LEE N 210
,Zurich 8092
, Switzerland
e-mail: mazza@imes.mavt.ethz.ch
John J. Moore
Division of Neonatology,
Case Western Reserve
e-mail: Jmoore@metrohealth.org
Case Western Reserve
University School of Medicine
,2500 MetroHealth Drive
,Cleveland, OH 44109
e-mail: Jmoore@metrohealth.org
1Corresponding author.
Manuscript received April 10, 2014; final manuscript received August 8, 2014; accepted manuscript posted August 29, 2014; published online September 17, 2014. Assoc. Editor: David Corr.
J Biomech Eng. Nov 2014, 136(11): 111009 (8 pages)
Published Online: September 17, 2014
Article history
Received:
April 10, 2014
Revision Received:
August 8, 2014
Accepted:
August 29, 2014
Citation
Bürzle, W., Mazza, E., and Moore, J. J. (September 17, 2014). "About Puncture Testing Applied for Mechanical Characterization of Fetal Membranes." ASME. J Biomech Eng. November 2014; 136(11): 111009. https://doi.org/10.1115/1.4028446
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