The purpose of this study is to investigate the effects of preconditioning on the deformation response of planar tissues measured by inflation tests. The inflation response of test specimens, including the bovine cornea, bovine and porcine sclera, and human skin, exhibited a negligible evolving deformation response when subjected to repeated pressure loading with recovery periods between cycles. Tissues obtained complete recovery to the reference state, and strain contours across the entire specimen were nearly identical at the maximum pressure of each load cycle. This repeatability was obtained regardless of strain history. These results suggest that negligible permanent change was induced in the microstructure by inflation testing. Additionally, we present data illustrating that a lack of a recovery period can result in an evolving deformation response to repeated loading that is commonly attributed to preconditioning. These results suggest that the commonly observed effects of preconditioning may be avoided by experimental design for planar tissues characterized by long collagen fibers arranged in the plane of the tissue. Specifically, if the test is designed to fully fix the specimen boundary during loading, adequate recovery periods are allowed after each load cycle, and loads are limited to avoid damage, preconditioning effects may be avoided for planar tissues.
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November 2013
Technical Briefs
Minimal Preconditioning Effects Observed for Inflation Tests of Planar Tissues
Baptiste Coudrillier,
The Johns Hopkins University,
Baptiste Coudrillier
Department of Mechanical Engineering
,The Johns Hopkins University,
Baltimore, MD 21218
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Stephen Alexander,
Boston University,
Stephen Alexander
Department of Biomedical Engineering
,Boston University,
Boston, MA 02215
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Thao D. Nguyen
Thao D. Nguyen
1
e-mail: vicky.nguyen@jhu.edu
The Johns Hopkins University,
Department of Mechanical Engineering
,The Johns Hopkins University,
Baltimore, MD 21218
1Corresponding author.
Search for other works by this author on:
Baptiste Coudrillier
Department of Mechanical Engineering
,The Johns Hopkins University,
Baltimore, MD 21218
Stephen Alexander
Department of Biomedical Engineering
,Boston University,
Boston, MA 02215
Thao D. Nguyen
e-mail: vicky.nguyen@jhu.edu
The Johns Hopkins University,
Department of Mechanical Engineering
,The Johns Hopkins University,
Baltimore, MD 21218
1Corresponding author.
Contributed by the Bioengineering Division of ASME for publication in the Journal of Biomechanical Engineering. Manuscript received December 19, 2012; final manuscript received July 17, 2013; accepted manuscript posted July 29, 2013; published online September 23, 2013. Assoc. Editor: Jeffrey Ruberti.
J Biomech Eng. Nov 2013, 135(11): 114502 (14 pages)
Published Online: September 23, 2013
Article history
Received:
December 19, 2012
Revision Received:
July 17, 2013
Accepted:
July 29, 2013
Citation
Tonge, T. K., Murienne, B. J., Coudrillier, B., Alexander, S., Rothkopf, W., and Nguyen, T. D. (September 23, 2013). "Minimal Preconditioning Effects Observed for Inflation Tests of Planar Tissues." ASME. J Biomech Eng. November 2013; 135(11): 114502. https://doi.org/10.1115/1.4025105
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