Porohyperviscoelastic (PHVE) modeling gives a simplified continuum approximation of pore fluid behavior within the parenchyma of liver tissue. This modeling approach is particularly applicable to tissue engineering of artificial livers, where the inherent complexity of the engineered scaffolds prevents the use of computational fluid dynamics. The objectives of this study were to simultaneously predict the experimental parenchymal fluid pressure (PFP) and compression response in a PHVE liver model. The model PFP matched the experimental measurements (318 Pa) to within 1.5%. Linear regression of both phases of compression, ramp, and hold, demonstrated a strong correlation between the model and the experimental reaction force (). The ability of this PVE model to accurately predict both fluid and solid behavior is important due to the highly vascularized nature of liver tissue and the mechanosensitivity of liver cells to solid matrix and fluid flow properties.
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devans@wakehealth.edu
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September 2012
Research Papers
Porohyperviscoelastic Model Simultaneously Predicts Parenchymal Fluid Pressure and Reaction Force in Perfused Liver
Emma C. Moran,
Emma C. Moran
Department of Biomedical Engineering, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157;
emoran@wakehealth.edu
Virginia-Tech Wake Forest University School of Biomedical Engineering and Sciences, Wake Forest University School of Medicine
, Medical Center Blvd., Winston-Salem, NC
27157
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Smitha Raghunathan,
Smitha Raghunathan
Department of Biomedical Engineering, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157;
Virginia-Tech Wake Forest University School of Biomedical Engineering and Sciences, Wake Forest University School of Medicine
, Medical Center Blvd., Winston-Salem, NC
27157
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Douglas W. Evans,
Douglas W. Evans
Department of Biomedical Engineering, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157;
devans@wakehealth.edu
Virginia-Tech Wake Forest University School of Biomedical Engineering and Sciences, Wake Forest University School of Medicine
, Medical Center Blvd., Winston-Salem, NC
27157
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Nicholas A. Vavalle,
Nicholas A. Vavalle
Department of Biomedical Engineering, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157;
nvavalle@wakehealth.edu
Virginia-Tech Wake Forest University School of Biomedical Engineering and Sciences, Wake Forest University School of Medicine
, Medical Center Blvd., Winston-Salem, NC
27157
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Jessica L. Sparks,
Jessica L. Sparks
Department of Biomedical Engineering, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157;
jsparks@wakehealth.edu
Virginia-Tech Wake Forest University School of Biomedical Engineering and Sciences, Wake Forest University School of Medicine
, Medical Center Blvd., Winston-Salem, NC
27157
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Tanya LeRoith,
tleroith@vt.edu
Tanya LeRoith
Department of Biomedical Sciences and Pathology, Virginia-Maryland Regional College of Veterinary Medicine
, Duckpond Drive, Phase II, Virginia Tech (0442), Blacksburg, VA
24061
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Thomas L. Smith
Thomas L. Smith
Department of Orthopaedics, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157
tsmith@wakehealth.edu
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Emma C. Moran
Department of Biomedical Engineering, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157;
Virginia-Tech Wake Forest University School of Biomedical Engineering and Sciences, Wake Forest University School of Medicine
, Medical Center Blvd., Winston-Salem, NC
27157emoran@wakehealth.edu
Smitha Raghunathan
Department of Biomedical Engineering, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157;
Virginia-Tech Wake Forest University School of Biomedical Engineering and Sciences, Wake Forest University School of Medicine
, Medical Center Blvd., Winston-Salem, NC
27157
Douglas W. Evans
Department of Biomedical Engineering, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157;
Virginia-Tech Wake Forest University School of Biomedical Engineering and Sciences, Wake Forest University School of Medicine
, Medical Center Blvd., Winston-Salem, NC
27157devans@wakehealth.edu
Nicholas A. Vavalle
Department of Biomedical Engineering, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157;
Virginia-Tech Wake Forest University School of Biomedical Engineering and Sciences, Wake Forest University School of Medicine
, Medical Center Blvd., Winston-Salem, NC
27157nvavalle@wakehealth.edu
Jessica L. Sparks
Department of Biomedical Engineering, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157;
Virginia-Tech Wake Forest University School of Biomedical Engineering and Sciences, Wake Forest University School of Medicine
, Medical Center Blvd., Winston-Salem, NC
27157jsparks@wakehealth.edu
Tanya LeRoith
Department of Biomedical Sciences and Pathology, Virginia-Maryland Regional College of Veterinary Medicine
, Duckpond Drive, Phase II, Virginia Tech (0442), Blacksburg, VA
24061tleroith@vt.edu
Thomas L. Smith
Department of Orthopaedics, Wake Forest University School of Medicine, Medical Center Blvd., Winston-Salem, NC 27157
tsmith@wakehealth.edu
J Biomech Eng. Sep 2012, 134(9): 091002 (9 pages)
Published Online: August 27, 2012
Article history
Received:
December 21, 2011
Revised:
July 12, 2012
Posted:
July 18, 2012
Published:
August 27, 2012
Online:
August 27, 2012
Connected Content
Citation
Moran, E. C., Raghunathan, S., Evans, D. W., Vavalle, N. A., Sparks, J. L., LeRoith, T., and Smith, T. L. (August 27, 2012). "Porohyperviscoelastic Model Simultaneously Predicts Parenchymal Fluid Pressure and Reaction Force in Perfused Liver." ASME. J Biomech Eng. September 2012; 134(9): 091002. https://doi.org/10.1115/1.4007175
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