Recent magnetic resonance studies have indicated that intraplaque hemorrhage (IPH) may accelerate plaque progression and play an important role in plaque destabilization. However, the impact of hemorrhage on critical plaque wall stress (CPWS) and strain (CPWSn) has yet to be determined. The objective of this study was to assess the effect of the presence and size of IPH on wall mechanics. The magnetic resonance image (MRI) of one patient with histology-confirmed IPH was used to build eight 3D fluid-structure interaction (FSI) models by altering the dimensions of the existing IPH. As a secondary end point, the combined effect of IPH and fibrous cap thickness (FCT) was assessed. A volume curve fitting method (VCFM) was applied to generate a mesh that would guarantee numerical convergence. Plaque wall stress (PWS), strain (PWSn), and flow shear stress (FSS) were extracted from all nodal points on the lumen surface for analysis. Keeping other conditions unchanged, the presence of intraplaque hemorrhage caused a significant increase (27.5%) in CPWS; reduced FCT caused an increase of 22.6% of CPWS. Similar results were found for CPWSn. Furthermore, combination of IPH presence, reduced FCT, and increased IPH volume caused an 85% and 75% increase in CPWS and CPWSn, respectively. These results show that intraplaque hemorrhage has considerable impact on plaque stress and strain conditions and accurate quantification of IPH could lead to more accurate assessment of plaque vulnerability. Large-scale studies are needed to further validate our findings.
Skip Nav Destination
Article navigation
December 2012
Research-Article
Quantifying Effect of Intraplaque Hemorrhage on Critical Plaque Wall Stress in Human Atherosclerotic Plaques Using Three-Dimensional Fluid-Structure Interaction Models
Xueying Huang,
Xueying Huang
1
School of Mathematical Sciences,
Xiamen University,
Xiamen, Fujian 361005, P. R. C.;
Mathematical Sciences Department,
e-mail: xhuang@xmu.edu.cn
Xiamen University,
Xiamen, Fujian 361005, P. R. C.;
Mathematical Sciences Department,
Worcester Polytechnic Institute
,Worcester, MA 01609
e-mail: xhuang@xmu.edu.cn
1Corresponding author. Present address: School of Mathematical Sciences, Xiamen University, Xiamen, Fujian 361005, P. R. C.
Search for other works by this author on:
Chun Yang,
Chun Yang
Mathematical Sciences Department,
Worcester Polytechnic Institute,
Worcester, MA 01609;
School of Mathematics,
Worcester Polytechnic Institute,
Worcester, MA 01609;
School of Mathematics,
Beijing Normal University
, Beijing 100875
, P. R. C.
Search for other works by this author on:
Gador Canton,
Gador Canton
Department of Mechanical Engineering,
University of Washington
,Seattle, WA 98195
Search for other works by this author on:
Chun Yuan,
Chun Yuan
Deparment of Radiology,
University of Washington
,Seattle, WA 98195
Search for other works by this author on:
Dalin Tang
Dalin Tang
Life Science and Biomedical Engineering Institute,
Southeast University,
Nanjing, Jiangsu 210096, P. R. C.;
Mathematical Sciences Department,
Southeast University,
Nanjing, Jiangsu 210096, P. R. C.;
Mathematical Sciences Department,
Worcester Polytechnic Institute
,Worcester, MA 01609
Search for other works by this author on:
Xueying Huang
School of Mathematical Sciences,
Xiamen University,
Xiamen, Fujian 361005, P. R. C.;
Mathematical Sciences Department,
e-mail: xhuang@xmu.edu.cn
Xiamen University,
Xiamen, Fujian 361005, P. R. C.;
Mathematical Sciences Department,
Worcester Polytechnic Institute
,Worcester, MA 01609
e-mail: xhuang@xmu.edu.cn
Chun Yang
Mathematical Sciences Department,
Worcester Polytechnic Institute,
Worcester, MA 01609;
School of Mathematics,
Worcester Polytechnic Institute,
Worcester, MA 01609;
School of Mathematics,
Beijing Normal University
, Beijing 100875
, P. R. C.
Gador Canton
Department of Mechanical Engineering,
University of Washington
,Seattle, WA 98195
Chun Yuan
Deparment of Radiology,
University of Washington
,Seattle, WA 98195
Dalin Tang
Life Science and Biomedical Engineering Institute,
Southeast University,
Nanjing, Jiangsu 210096, P. R. C.;
Mathematical Sciences Department,
Southeast University,
Nanjing, Jiangsu 210096, P. R. C.;
Mathematical Sciences Department,
Worcester Polytechnic Institute
,Worcester, MA 01609
1Corresponding author. Present address: School of Mathematical Sciences, Xiamen University, Xiamen, Fujian 361005, P. R. C.
Contributed by the Bioengineering Division of ASME for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING Manuscript received June 13, 2012; final manuscript received October 8, 2012; accepted manuscript posted October 25, 2012; published online November 27, 2012. Assoc. Editor: Ender A. Finol.
J Biomech Eng. Dec 2012, 134(12): 121004 (9 pages)
Published Online: November 27, 2012
Article history
Received:
June 13, 2012
Revision Received:
October 8, 2012
Accepted:
October 25, 2012
Citation
Huang, X., Yang, C., Canton, G., Ferguson, M., Yuan, C., and Tang, D. (November 27, 2012). "Quantifying Effect of Intraplaque Hemorrhage on Critical Plaque Wall Stress in Human Atherosclerotic Plaques Using Three-Dimensional Fluid-Structure Interaction Models." ASME. J Biomech Eng. December 2012; 134(12): 121004. https://doi.org/10.1115/1.4007954
Download citation file:
Get Email Alerts
Continuous Softening as a State of Hyperelasticity: Examples of Application to the Softening Behavior of the Brain Tissue
J Biomech Eng (September 2024)
Changes in Dynamic Mean Ankle Moment Arm in Unimpaired Walking Across Speeds, Ramps, and Stairs
J Biomech Eng (September 2024)
Related Articles
In Vivo Serial MRI-Based Models and Statistical Methods to Quantify Sensitivity and Specificity of Mechanical Predictors for Carotid Plaque Rupture: Location and Beyond
J Biomech Eng (June,2011)
3D MRI-Based Anisotropic FSI Models With Cyclic Bending for Human Coronary Atherosclerotic Plaque Mechanical Analysis
J Biomech Eng (June,2009)
Related Proceedings Papers
Related Chapters
Introduction
Ultrasonic Methods for Measurement of Small Motion and Deformation of Biological Tissues for Assessment of Viscoelasticity
Applications
Introduction to Finite Element, Boundary Element, and Meshless Methods: With Applications to Heat Transfer and Fluid Flow
Acoustic Noise in MRI Scanners
Biomedical Applications of Vibration and Acoustics in Therapy, Bioeffect and Modeling