Recent magnetic resonance studies have indicated that intraplaque hemorrhage (IPH) may accelerate plaque progression and play an important role in plaque destabilization. However, the impact of hemorrhage on critical plaque wall stress (CPWS) and strain (CPWSn) has yet to be determined. The objective of this study was to assess the effect of the presence and size of IPH on wall mechanics. The magnetic resonance image (MRI) of one patient with histology-confirmed IPH was used to build eight 3D fluid-structure interaction (FSI) models by altering the dimensions of the existing IPH. As a secondary end point, the combined effect of IPH and fibrous cap thickness (FCT) was assessed. A volume curve fitting method (VCFM) was applied to generate a mesh that would guarantee numerical convergence. Plaque wall stress (PWS), strain (PWSn), and flow shear stress (FSS) were extracted from all nodal points on the lumen surface for analysis. Keeping other conditions unchanged, the presence of intraplaque hemorrhage caused a significant increase (27.5%) in CPWS; reduced FCT caused an increase of 22.6% of CPWS. Similar results were found for CPWSn. Furthermore, combination of IPH presence, reduced FCT, and increased IPH volume caused an 85% and 75% increase in CPWS and CPWSn, respectively. These results show that intraplaque hemorrhage has considerable impact on plaque stress and strain conditions and accurate quantification of IPH could lead to more accurate assessment of plaque vulnerability. Large-scale studies are needed to further validate our findings.
Quantifying Effect of Intraplaque Hemorrhage on Critical Plaque Wall Stress in Human Atherosclerotic Plaques Using Three-Dimensional Fluid-Structure Interaction Models
Worcester Polytechnic Institute,
Worcester, MA 01609;
School of Mathematics,
Nanjing, Jiangsu 210096, P. R. C.;
Mathematical Sciences Department,
Contributed by the Bioengineering Division of ASME for publication in the JOURNAL OF BIOMECHANICAL ENGINEERING Manuscript received June 13, 2012; final manuscript received October 8, 2012; accepted manuscript posted October 25, 2012; published online November 27, 2012. Assoc. Editor: Ender A. Finol.
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Huang, X., Yang, C., Canton, G., Ferguson, M., Yuan, C., and Tang, D. (November 27, 2012). "Quantifying Effect of Intraplaque Hemorrhage on Critical Plaque Wall Stress in Human Atherosclerotic Plaques Using Three-Dimensional Fluid-Structure Interaction Models." ASME. J Biomech Eng. December 2012; 134(12): 121004. https://doi.org/10.1115/1.4007954
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