Background. In vivo experimentation is the most realistic approach for exploring the vascular biological response to the hemodynamic stresses that are present in life. Post-mortem vascular casting has been used to define the in vivo geometry for hemodynamic simulation; however, this procedure damages or destroys the tissue and cells on which biological assays are to be performed. Method of Approach. Two statistical approaches, regional (RSH) and linear (LSH) statistical hemodynamics, are proposed and illustrated, in which flow simulations from one series of experiments are used to define a best estimate of the hemodynamic environment in a second series. As an illustration of the technique, RSH is used to compare the gene expression profiles of regions of the proximal external iliac arteries of swine exposed to different levels of time-average shear stress. Results. The results indicate that higher shears promote a more atheroprotective expression phenotype in porcine arterial endothelium. Conclusion. Statistical hemodynamics provides a realistic estimate of the hemodynamic stress on vascular tissue that can be correlated against biological response.
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December 2006
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Statistical Hemodynamics: A Tool for Evaluating the Effect of Fluid Dynamic Forces on Vascular Biology In Vivo
Morton H. Friedman,
Morton H. Friedman
Duke University
, Department of Biomedical Engineering, Box 90281, Durham, NC 27708
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Heather A. Himburg,
Heather A. Himburg
Duke University
, Department of Biomedical Engineering, Box 90281, Durham, NC 27708
Search for other works by this author on:
Jeffrey A. LaMack
Jeffrey A. LaMack
Duke University
, Department of Biomedical Engineering, Box 90281, Durham, NC 27708
Search for other works by this author on:
Morton H. Friedman
Duke University
, Department of Biomedical Engineering, Box 90281, Durham, NC 27708
Heather A. Himburg
Duke University
, Department of Biomedical Engineering, Box 90281, Durham, NC 27708
Jeffrey A. LaMack
Duke University
, Department of Biomedical Engineering, Box 90281, Durham, NC 27708J Biomech Eng. Dec 2006, 128(6): 965-968 (4 pages)
Published Online: May 16, 2006
Article history
Received:
September 14, 2005
Revised:
May 16, 2006
Citation
Friedman, M. H., Himburg, H. A., and LaMack, J. A. (May 16, 2006). "Statistical Hemodynamics: A Tool for Evaluating the Effect of Fluid Dynamic Forces on Vascular Biology In Vivo." ASME. J Biomech Eng. December 2006; 128(6): 965–968. https://doi.org/10.1115/1.2354212
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