Nano-Mechanical Properties of Human Meniscal Surfaces

Osteoarthritis (OA) is a crippling disease in humans that deteriorates the articular cartilage (AC) and subchondral bone. Research has shown AC preservation is most important for halting the initiation of OA, in the human knee joint, and this defense is contingent on the structural integrity of the menisci [1, 2]. The menisci are fibrocartilaginous structures which are crucial for proper load distribution in the knee [3–5]. The menisci are specifically designed to fit the contour of the femoral condyles, aiding to disperse the stresses on the tibial plateau and in turn safeguarding the underlying AC. Circumferentially aligned collagen fibers help to support the menisci while in tension, while a proteoglycan and water matrix reinforce the menisci during compressive loads [2, 6].