Bicuspid aortic valve (BAV) is the most common congenital heart malformation occurring in 1–2% of the population with a high rate of morbidity [1]. There is a significantly higher rate of dilation of the aortic root in adults with a BAV when compared to the normal population and this condition is often associated with ascending thoracic aortic aneurysm (ATAA). ATAA is characterized as an enlargement of the aorta to twice its normal diameter. If left untreated, ATAA can lead to aortic dissection or rupture. Therefore, ATAA is recommended for prophylactic surgery when its diameter reaches about 5.5 cm. However, in certain high-risk cases, such as patients with BAV, ATAA may rupture when its diameter is less than 5.5 cm. Since ATAA dissection and rupture are biomechanical phenomena, better mechanical models are needed to more accurately predict these events over the predictive capability of diameter alone.
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ASME 2011 Summer Bioengineering Conference
June 22–25, 2011
Farmington, Pennsylvania, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-5458-7
PROCEEDINGS PAPER
Association of Mechanical Properties and Collagen Content With Valve Morphology in Ascending Thoracic Aortic Aneurysmal Tissue
Joseph E. Pichamuthu,
Joseph E. Pichamuthu
University of Pittsburgh, Pittsburgh, PA
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Julie A. Phillippi,
Julie A. Phillippi
University of Pittsburgh, Pittsburgh, PA
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Deborah A. Cleary,
Deborah A. Cleary
University of Pittsburgh, Pittsburgh, PA
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Douglas W. Chew,
Douglas W. Chew
University of Pittsburgh, Pittsburgh, PA
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John Hempel,
John Hempel
University of Pittsburgh, Pittsburgh, PA
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Thomas G. Gleason,
Thomas G. Gleason
University of Pittsburgh, Pittsburgh, PA
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David A. Vorp
David A. Vorp
University of Pittsburgh, Pittsburgh, PA
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Joseph E. Pichamuthu
University of Pittsburgh, Pittsburgh, PA
Julie A. Phillippi
University of Pittsburgh, Pittsburgh, PA
Deborah A. Cleary
University of Pittsburgh, Pittsburgh, PA
Douglas W. Chew
University of Pittsburgh, Pittsburgh, PA
John Hempel
University of Pittsburgh, Pittsburgh, PA
Thomas G. Gleason
University of Pittsburgh, Pittsburgh, PA
David A. Vorp
University of Pittsburgh, Pittsburgh, PA
Paper No:
SBC2011-53873, pp. 69-70; 2 pages
Published Online:
July 17, 2013
Citation
Pichamuthu, JE, Phillippi, JA, Cleary, DA, Chew, DW, Hempel, J, Gleason, TG, & Vorp, DA. "Association of Mechanical Properties and Collagen Content With Valve Morphology in Ascending Thoracic Aortic Aneurysmal Tissue." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 69-70. ASME. https://doi.org/10.1115/SBC2011-53873
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