Cancer remains one of the most deadly diseases today. Laser-induced photothermal therapy can provide a minimally invasive treatment alternative to surgical resection. The selectivity and effectiveness of laser therapy can be greatly enhanced when photoabsorbing nanoparticles such as nanoshells, single walled carbon nanotubes, multi-walled carbon nanotubes, or single wall carbon nanohorns (SWNHs) are introduced into the tissue. Prior studies have effectively used SWNHs combined with near infrared (NIR) laser light to target and destroy microbes [1]. We have previously reported increased tumor cell destruction when SWNHs were used in combination with laser therapy. The present work provides more extensive characterization of cell viability in response to laser therapy alone or in combination with SWNHs. Furthermore, the spatiotemporal temperature and cell viability in vitro in response to combinatorial SWNH-mediated laser therapies is determined using infrared thermometry and a novel viability algorithm, respectively. These new measurements will be critical for planning SWNH-mediated laser treatments where knowledge of the geometric distribution of temperature and cell death are critical to achieving the goal of selectively eliminating a tumor with specific spatial margins with minimal damage to surrounding healthy tissue.
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ASME 2010 Summer Bioengineering Conference
June 16–19, 2010
Naples, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4403-8
PROCEEDINGS PAPER
Spatiotemporal Temperature and Cell Viability Measurement Following Laser Therapy in Combination With Carbon Nanohorns
Chris Rylander,
Chris Rylander
Virginia Tech, Blacksburg, VA
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David Geohegan,
David Geohegan
Oak Ridge National Labs, Oak Ridge, TN
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Marissa Nichole Rylander
Marissa Nichole Rylander
Virginia Tech, Blacksburg, VA
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Jon Whitney
Virginia Tech, Blacksburg, VA
Harry Dorn
Virginia Tech, Blacksburg, VA
Chris Rylander
Virginia Tech, Blacksburg, VA
Tom Campbell
Virginia Tech, Blacksburg, VA
David Geohegan
Oak Ridge National Labs, Oak Ridge, TN
Marissa Nichole Rylander
Virginia Tech, Blacksburg, VA
Paper No:
SBC2010-19619, pp. 79-80; 2 pages
Published Online:
July 15, 2013
Citation
Whitney, J, Dorn, H, Rylander, C, Campbell, T, Geohegan, D, & Rylander, MN. "Spatiotemporal Temperature and Cell Viability Measurement Following Laser Therapy in Combination With Carbon Nanohorns." Proceedings of the ASME 2010 Summer Bioengineering Conference. ASME 2010 Summer Bioengineering Conference, Parts A and B. Naples, Florida, USA. June 16–19, 2010. pp. 79-80. ASME. https://doi.org/10.1115/SBC2010-19619
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