Quantitative, 3-D Imaging to Co-Localize Bone and Vasculature Tissues During Bone Healing

Successful bone repair requires reestablishment of a blood supply at the injury site [1]. However, despite convincing evidence of the close relationship between angiogenesis and osteogenesis during bone healing, little is known about the spatial correspondence between these two processes. This paucity of information hampers understanding of the mechanisms regulating osteogenesis during bone healing and of how molecular communication between endothelial cells and osteoblasts mediates the restoration of mechanical function.