Osmotic stress affects biological function in articular chondrocytes and plays an important role in mechanotransduction in articular cartilage. One potential pathway for osmotic sensitivity in chondrocytes is direct deformation of the nucleus by osmotic stress [1,2]. However, the mechanism of this phenomenon is currently unclear. The nucleus is not contained within a semi-permeable lipid bilayer as are most osmotically sensitive organelles. It is conceivable that fixed charges in chromatin might attract dissolved ions and render it osmotically sensitive. However, this model cannot account for the abolition of the osmotic sensitivity of the nucleus by permeabilization of the cell membrane [3]. The goal of this study was to characterize the osmotic sensitivity of the chondrocyte nucleus and determine the underlying mechanism.
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ASME 2009 Summer Bioengineering Conference
June 17–21, 2009
Lake Tahoe, California, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4891-3
PROCEEDINGS PAPER
Nonlinear Osmotic Properties of the Cell Nucleus
Kevin J. Chalut,
Kevin J. Chalut
Duke University, Durham, NC
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Farshid Guilak
Farshid Guilak
Duke University, Durham, NC
Search for other works by this author on:
John D. Finan
Duke University, Durham, NC
Kevin J. Chalut
Duke University, Durham, NC
Adam Wax
Duke University, Durham, NC
Farshid Guilak
Duke University, Durham, NC
Paper No:
SBC2009-206197, pp. 93-94; 2 pages
Published Online:
July 19, 2013
Citation
Finan, JD, Chalut, KJ, Wax, A, & Guilak, F. "Nonlinear Osmotic Properties of the Cell Nucleus." Proceedings of the ASME 2009 Summer Bioengineering Conference. ASME 2009 Summer Bioengineering Conference, Parts A and B. Lake Tahoe, California, USA. June 17–21, 2009. pp. 93-94. ASME. https://doi.org/10.1115/SBC2009-206197
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