The Expression of A-Type Lamins as a Regulator of Mechanics of the Nucleus and Cell Mechanotransduction

Mechanotransduction of extracellular stimuli into the chromatin located in the cell nucleus and overall cell mechanics may require the physical support of structures of A-type lamins. Several cellular pathologic phenotypes and phases of stem cell differentiation involve regulation and reorganization of A-type lamins. Here is presented a study of changes in cell mechanics associated to the reorganization of nuclear structures consequent to knockdown of A-type lamins. Transient dysmophism of the cell nucleus is observed during knockdown of A-type lamins, which seems to be driven by inner cellular forces resultant of cytoskeletal and chromatin structural reorganization.