Proteoglycans and Type II collagen represent the two major biochemical constituents of articular cartilage. Collagen fibrils in cartilage resist the swelling pressure that arises from the fixed charges of the glycosaminoglycans (GAGs), and together they give rise to the tissue’s unique load bearing properties. As articular cartilage exhibits a poor intrinsic healing capacity, there is significant research in the development of cell-based therapies for cartilage repair. In some of our tissue engineering studies, we have observed a phenomenon where chondrocyte-seeded hydrogel constructs display cracking in their central regions after significant GAG content has been elaborated in culture. A theoretical analysis was performed to gain greater insights into the potential role that the spatial distribution of proteoglycan and collagen may play in this observed response.
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ASME 2008 Summer Bioengineering Conference
June 25–29, 2008
Marco Island, Florida, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4321-5
PROCEEDINGS PAPER
Finite Element Modeling of Osmotic Swelling in Tissue-Engineered Cartilage
Liming Bian,
Liming Bian
Columbia University, New York, NY
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Terri Ann N. Kelly,
Terri Ann N. Kelly
Columbia University, New York, NY
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Eric G. Lima,
Eric G. Lima
Columbia University, New York, NY
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Gerard A. Ateshian,
Gerard A. Ateshian
Columbia University, New York, NY
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Clark T. Hung
Clark T. Hung
Columbia University, New York, NY
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Liming Bian
Columbia University, New York, NY
Terri Ann N. Kelly
Columbia University, New York, NY
Eric G. Lima
Columbia University, New York, NY
Gerard A. Ateshian
Columbia University, New York, NY
Clark T. Hung
Columbia University, New York, NY
Paper No:
SBC2008-192368, pp. 269-270; 2 pages
Published Online:
March 13, 2014
Citation
Bian, L, Kelly, TAN, Lima, EG, Ateshian, GA, & Hung, CT. "Finite Element Modeling of Osmotic Swelling in Tissue-Engineered Cartilage." Proceedings of the ASME 2008 Summer Bioengineering Conference. ASME 2008 Summer Bioengineering Conference, Parts A and B. Marco Island, Florida, USA. June 25–29, 2008. pp. 269-270. ASME. https://doi.org/10.1115/SBC2008-192368
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