Magnetic nanoparticles (mNPs) are known to heat and produce contrast for magnetic resonance imaging (MRI) in response to varying magnetic fields. These phenomena are being clinically applied in the detection and treatment of diseases such as cancer. However, one important factor that has been largely overlooked in the field is the effect of aggregation on the mNPs’ performance once they are delivered into target cells and tissues. Specifically, nanoparticle aggregation caused by protein interactions and cellular uptake can lead to shifts in their behavior due to increases in the interparticle magnetic interactions and changes to Brownian motion. This will affect both the mNPs’ ability to heat and to be imaged by MRI.
- Bioengineering Division
Accounting for Aggregation in Heating and Imaging of Magnetic Nanoparticles for Application in Thermal Therapies
- Views Icon Views
- Share Icon Share
- Search Site
Etheridge, ML, Zhang, J, Garwood, M, & Bischof, JC. "Accounting for Aggregation in Heating and Imaging of Magnetic Nanoparticles for Application in Thermal Therapies." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions. Sunriver, Oregon, USA. June 26–29, 2013. V01BT42A002. ASME. https://doi.org/10.1115/SBC2013-14325
Download citation file: