Skeletal muscle loss, through injuries, myopathies, and interventional medicine, presents major challenges in physiological function and clinical interventions . Autologous tissue transplantation necessitates tissue loss from the donor site, and autologous grafts do not attain the strength of the original tissue. Exogenous tissue grafting faces similar strength issues, as well as the added challenge of immunorejection [2,3]. In vitro skeletal muscle tissue engineering holds promise for addressing these issues. However, these tissues have not yet shown proper dynamic response when compared to physiological muscle . Mechanical and electrical stimulation have shown promise in improving construct properties , but mainly limited to 2D and scaffold-based constructs.
- Bioengineering Division
Mechanical and Electrical Stimulation Induces Calcium-Sensitive Mechanical Properties of Myoblast Derived Engineered Fibers
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Mason, AK, Koppes, RA, Swank, DM, & Corr, DT. "Mechanical and Electrical Stimulation Induces Calcium-Sensitive Mechanical Properties of Myoblast Derived Engineered Fibers." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions. Sunriver, Oregon, USA. June 26–29, 2013. V01BT39A010. ASME. https://doi.org/10.1115/SBC2013-14646
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