Knowledge of patient-specific muscle and joint contact forces during activities of daily living could improve the treatment of movement-related disorders (e.g., osteoarthritis, stroke, cerebral palsy, Parkinson’s disease). Unfortunately, it is currently impossible to measure these quantities directly under common clinical conditions, and calculation of these quantities using computer models is limited by the redundant nature of human neural control (i.e., more muscles than theoretically necessary to actuate the available degrees of freedom in the skeleton). Walking is a particularly important task to understand, since loss of mobility is associated with increased morbidity and decreased quality of life . Though numerous musculoskeletal computer modeling studies have used optimization methods to resolve the neural control redundancy problem, these estimates remain unvalidated due to the lack of internal force measurements that can be used for validation purposes.
- Bioengineering Division
Muscle Synergy Constraints Improve Prediction of Knee Contact Force During Gait
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Fregly, BJ, Walter, JP, Kinney, AL, Banks, SA, D’Lima, DD, Besier, TF, & Lloyd, DG. "Muscle Synergy Constraints Improve Prediction of Knee Contact Force During Gait." Proceedings of the ASME 2013 Summer Bioengineering Conference. Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions. Sunriver, Oregon, USA. June 26–29, 2013. V01BT34A006. ASME. https://doi.org/10.1115/SBC2013-14782
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