The mammalian cochlea is an acoustic spectrum analyzer and pressure transducer with a remarkable operating range, both in frequency and amplitude (Fettiplace & Hackney, 2006). A young healthy human ear can capture sounds of 40 to 20,000 Hz in frequency and 20 μPa to 20 Pa (0 to 120 dB sound pressure level) in amplitude. In research on the cochlea, one of the most significant achievements in decades is the identification of the cochlear amplifier. Tiny acoustic vibrations are amplified in the organ of Corti (OC)—sensori-eptithelium in the cochlea. Mechano-transducer receptors in the OC, called the outer hair cells, have been identified as the cellular actuators that provide energy to boost small pressure waves. However, how the amplification is achieved is still unclear.
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ASME 2012 Summer Bioengineering Conference
June 20–23, 2012
Fajardo, Puerto Rico, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4480-9
PROCEEDINGS PAPER
Microchamber System to Experiment Mechanotransduction in the Organ of Corti
Paul Narr,
Paul Narr
University of Rochester, Rochester, NY
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Alex Ringo,
Alex Ringo
University of Rochester, Rochester, NY
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Daniel Marnell,
Daniel Marnell
University of Rochester, Rochester, NY
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Jong-Hoon Nam
Jong-Hoon Nam
University of Rochester, Rochester, NY
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Paul Narr
University of Rochester, Rochester, NY
Alex Ringo
University of Rochester, Rochester, NY
Daniel Marnell
University of Rochester, Rochester, NY
Jong-Hoon Nam
University of Rochester, Rochester, NY
Paper No:
SBC2012-80137, pp. 681-682; 2 pages
Published Online:
July 19, 2013
Citation
Narr, P, Ringo, A, Marnell, D, & Nam, J. "Microchamber System to Experiment Mechanotransduction in the Organ of Corti." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 681-682. ASME. https://doi.org/10.1115/SBC2012-80137
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