In the last decade electrospinning has shown its potential of being a feasible technique to manufacture scaffolds for tissue engineering . Previous studies observed that, on a micrometer scale, the topology of the scaffold plays a fundamental role in the spreading and the differentiation of the cells , and in the growth of neo-extracellular matrix. On a tissue scale (in the order of cm) the stiffness of the construct enables the possibility of applying mechanical cues for the development of a functional engineered tissue . Studies on scaffold mechanics based on volume-averaging theory succeeded in demonstrating that the arrangement of the micro-scale scaffold components influences the macro-scale mechanical behavior .
- Bioengineering Division
Mechanics of Electrospun Scaffolds: An Application to Heart Valve Tissue Engineering
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Argento, G, Simonet, M, Oomens, CWJ, & Baaijens, FPT. "Mechanics of Electrospun Scaffolds: An Application to Heart Valve Tissue Engineering." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 571-572. ASME. https://doi.org/10.1115/SBC2012-80724
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