The clinical need for alternatives to autologous vein and artery grafts for small-diameter vascular reconstruction have led researches to a tissue-engineering approach. Bioengineered vascular grafts provide a mechanically robust conduit for blood flow while implanted autologous cells remodel the construct to form a fully functional vessel . A typical tissue-engineering approach involves fabricating a vascular scaffold from natural or synthetic materials, seeding the lumen of a vessel with endothelial cells (EC) and the vessel wall with smooth muscle cells or fibroblasts to mimic the functional properties of a native vessel. The cell-seeded vascular scaffold is then preconditioned in vitro using a pulsatile bioreactor to mimic in vivo conditions to enhance vessel maturation before implantation (Fig. 1).
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A Nondestructive Fiber-Based Imaging System to Assess Tissue-Engineered Vascular Grafts
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Whited, BM, Hofmann, MC, Lu, P, Rylander, CG, Soker, S, Wang, G, Xu, Y, & Rylander, MN. "A Nondestructive Fiber-Based Imaging System to Assess Tissue-Engineered Vascular Grafts." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 493-494. ASME. https://doi.org/10.1115/SBC2012-80298
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