Much effort has been recently directed to investigate how soluble factors in the local cellular microenvironment of embryonic stem cells (ESCs) regulate their fate decisions [1]; however, effects of mechanical signals in the local cellular microenvironment on the fates of ESCs are still not yet well understood. Early experimental evidence established in recent years has shown that mechanical signals and external forces experienced through interactions with extracellular matrix (ECM) mechanics can play critical roles in regulating survival, proliferation and differentiation of ESCs. However, there is still limited knowledge of how mechanical signals in the local cellular microenvironment regulate the fate decisions of human ESCs (hESCs), and advancing such knowledge will be critical for both fundamental understanding and clinical applications of hESCs. This work was thus set to explicitly investigate the mechanosensitive properties of hESCs.
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ASME 2012 Summer Bioengineering Conference
June 20–23, 2012
Fajardo, Puerto Rico, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-4480-9
PROCEEDINGS PAPER
Investigation of Mechanoresponsive Behaviors of Human Embryonic Stem Cells Using Microfabricated Elastomeric Post Arrays
Yubing Sun,
Yubing Sun
University of Michigan, Ann Arbor, MI
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Luis G. Villa-Diaz,
Luis G. Villa-Diaz
University of Michigan, Ann Arbor, MI
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Raymond H. W. Lam,
Raymond H. W. Lam
University of Michigan, Ann Arbor, MI
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Weiqiang Chen,
Weiqiang Chen
University of Michigan, Ann Arbor, MI
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Paul H. Krebsbach,
Paul H. Krebsbach
University of Michigan, Ann Arbor, MI
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Jianping Fu
Jianping Fu
University of Michigan, Ann Arbor, MI
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Yubing Sun
University of Michigan, Ann Arbor, MI
Luis G. Villa-Diaz
University of Michigan, Ann Arbor, MI
Raymond H. W. Lam
University of Michigan, Ann Arbor, MI
Weiqiang Chen
University of Michigan, Ann Arbor, MI
Paul H. Krebsbach
University of Michigan, Ann Arbor, MI
Jianping Fu
University of Michigan, Ann Arbor, MI
Paper No:
SBC2012-80269, pp. 317-318; 2 pages
Published Online:
July 19, 2013
Citation
Sun, Y, Villa-Diaz, LG, Lam, RHW, Chen, W, Krebsbach, PH, & Fu, J. "Investigation of Mechanoresponsive Behaviors of Human Embryonic Stem Cells Using Microfabricated Elastomeric Post Arrays." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 317-318. ASME. https://doi.org/10.1115/SBC2012-80269
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