Pulmonary hypertension (PH) is a complex disorder that manifests as abnormally high blood pressure in the vasculature of the lungs. The chronic structural and mechanical changes in the proximal pulmonary artery (PA) associated with PH include smooth muscle cell hypertrophy and proliferation, accumulation of extracellular matrix (ECM) protein and increased stiffness1–4. Recent evidence has shown that conduit PA stiffness is a strong predictor of mortality in pulmonary arterial hypertension5,6. This suggests a potential association between large PA biomechanics and right ventricle failure.
- Bioengineering Division
Changes in Conduit Pulmonary Arterial Static and Dynamic Mechanical Properties During Severe Hypoxic Pulmonary Hypertension
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Wang, Z, Lakes, RS, & Chesler, NC. "Changes in Conduit Pulmonary Arterial Static and Dynamic Mechanical Properties During Severe Hypoxic Pulmonary Hypertension." Proceedings of the ASME 2012 Summer Bioengineering Conference. ASME 2012 Summer Bioengineering Conference, Parts A and B. Fajardo, Puerto Rico, USA. June 20–23, 2012. pp. 1333-1334. ASME. https://doi.org/10.1115/SBC2012-80382
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