The specialized function of articular cartilage in distributing stresses during normal joint movement must be recapitulated in a successful engineered cartilage repair. Chondrocytes can generate in vitro cartilage constructs with mechanical properties at or near native levels [1–3] when cultured in specialized media formulations. While these advances in chondrocyte-based tissue engineering are highly instructive, the difficulty of obtaining sufficient numbers of healthy autologous chondrocytes represents a considerable challenge. To circumvent this limitation, many have evaluated mesenchymal stem cells (MSCs), an autologous cell type that can be expanded in vitro and with a demonstrated capacity for chondrogenic differentiation. Despite their potential, MSC-based engineered cartilage has yet to achieve functional properties comparable to those produced by chondrocytes in 3D culture [4–6].
Skip Nav Destination
ASME 2011 Summer Bioengineering Conference
June 22–25, 2011
Farmington, Pennsylvania, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-5458-7
PROCEEDINGS PAPER
Dynamic Compression Promotes Cartilage-Like Functional Properties in MSC-Seeded Hyaluronic Acid Hydrogels
Isaac E. Erickson,
Isaac E. Erickson
University of Pennsylvania, Philadelphia, PA
Search for other works by this author on:
Kilief H. Zellars,
Kilief H. Zellars
University of Pennsylvania, Philadelphia, PA
Search for other works by this author on:
Sydney R. Kestle,
Sydney R. Kestle
University of Pennsylvania, Philadelphia, PA
Search for other works by this author on:
Jason A. Burdick,
Jason A. Burdick
University of Pennsylvania, Philadelphia, PA
Search for other works by this author on:
Robert L. Mauck
Robert L. Mauck
University of Pennsylvania, Philadelphia, PA
Search for other works by this author on:
Isaac E. Erickson
University of Pennsylvania, Philadelphia, PA
Kilief H. Zellars
University of Pennsylvania, Philadelphia, PA
Sydney R. Kestle
University of Pennsylvania, Philadelphia, PA
Jason A. Burdick
University of Pennsylvania, Philadelphia, PA
Robert L. Mauck
University of Pennsylvania, Philadelphia, PA
Paper No:
SBC2011-53661, pp. 891-892; 2 pages
Published Online:
July 17, 2013
Citation
Erickson, IE, Zellars, KH, Kestle, SR, Burdick, JA, & Mauck, RL. "Dynamic Compression Promotes Cartilage-Like Functional Properties in MSC-Seeded Hyaluronic Acid Hydrogels." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 891-892. ASME. https://doi.org/10.1115/SBC2011-53661
Download citation file:
2
Views
0
Citations
Related Proceedings Papers
Related Articles
Related Chapters
Effects of Ultrasound Stimulation on Chondrocytes in Three-Dimensional Culture in Relation to the Production of Regenerative Cartilage Tissue
Biomedical Applications of Vibration and Acoustics in Therapy, Bioeffect and Modeling
Synthesis and Characterization of Carboxymethyl Chitosan Based Hybrid Biopolymer Scaffold
International Conference on Mechanical and Electrical Technology, 3rd, (ICMET-China 2011), Volumes 1–3
Mechanical Analysis
Pipeline Pumping and Compression System: A Practical Approach, Third Edition