Recent studies have revealed that carotid arteries from fibulin-5 (fbln5) null mice exhibit altered biomechanical and microstructural properties [1–2]. While the previous studies outline quantitative differences in mechanical properties of arteries from fbln5 null and wildtype mice, physical microstructural differences have yet to be quantified. Measurement of microstructural parameters will provide a crucial link between previously quantified mechanical properties and biological effects of knocking out the fbln5 gene. Characterizing microstructural properties will also provide experimental data to validate structurally-motivated constitutive relations and growth and remodeling models [3–4]. In this study, we quantified collagen fiber orientation in carotid arteries from fbln5 null and wildtype mice; collagen in mouse carotid arteries were imaged using multiphoton microscopy and analyzed using a fast Fourier transform algorithm.
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ASME 2011 Summer Bioengineering Conference
June 22–25, 2011
Farmington, Pennsylvania, USA
Conference Sponsors:
- Bioengineering Division
ISBN:
978-0-7918-5458-7
PROCEEDINGS PAPER
Collagen Fiber Angle Quantification of Carotid Arteries From Fibulin-5 Null Mice
William Wan,
William Wan
Georgia Institute of Technology, Atlanta, GA
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Rudolph L. Gleason, Jr.
Rudolph L. Gleason, Jr.
Georgia Institute of Technology, Atlanta, GA
Search for other works by this author on:
William Wan
Georgia Institute of Technology, Atlanta, GA
Rudolph L. Gleason, Jr.
Georgia Institute of Technology, Atlanta, GA
Paper No:
SBC2011-53685, pp. 801-802; 2 pages
Published Online:
July 17, 2013
Citation
Wan, W, & Gleason, RL, Jr. "Collagen Fiber Angle Quantification of Carotid Arteries From Fibulin-5 Null Mice." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 801-802. ASME. https://doi.org/10.1115/SBC2011-53685
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