Mechanical Stimulation Provides the Key Induction Signal for Tenogenic Differentiation of Human Mesenchymal Stem Cells in Braided Nanofibrous Scaffolds

Tendon injury frequently occurs to the people who actively participate in physical or recreational activities. For example, in the U.S., there are more than 250,000 Achilles tendon injuries annually. The orthopedic problem causes significant burdens on the health care system and the economy because of costly patient care and loss of patients’ work productivity.