Mechanical forces play a critical role in the regulation of cell spreading and cytoskeletal organization. It has been demonstrated that the force required to compress a spread cell is significantly higher than that required to compress a cell with a rounded morphology . This increase in force can not be attributed to morphological changes alone , highlighting the importance of cytoskeletal remodeling during cell spreading in the resistance of cells to compressive forces.
- Bioengineering Division
Compression Force Measurement During Cell Spreading Using a Modified Atomic Force Microscope
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Weafer, P, van Es, MH, Jarvis, SP, & McGarry, PJ. "Compression Force Measurement During Cell Spreading Using a Modified Atomic Force Microscope." Proceedings of the ASME 2011 Summer Bioengineering Conference. ASME 2011 Summer Bioengineering Conference, Parts A and B. Farmington, Pennsylvania, USA. June 22–25, 2011. pp. 353-354. ASME. https://doi.org/10.1115/SBC2011-53741
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